4-Chloro-2-(chloromethyl)-6-fluoroquinazoline CAS 147003-97-2
| CAS No. | 147003-97-2 |
| Molecular Formula | C9H5Cl2FN2 |
| Molecular Weight | 231.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-2-(chloromethyl)-6-fluoroquinazoline.
CATO supplies 4-Chloro-2-(chloromethyl)-6-fluoroquinazoline (CAS 147003-97-2), a certified reference material (molecular formula C9H5Cl2FN2, MW 231.05 g/mol) for analytical method development and quality control.
The molecular framework of 4-Chloro-2-(chloromethyl)-6-fluoroquinazoline (C9H5Cl2FN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-2-(chloromethyl)-6-fluoroquinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H5Cl2FN2 |
| Molecular Weight | 231.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 6-Chloro-9-(3-chloropropyl)-9H-purine (CAS 113379-30-9)
- 2-Chloro-1-[3-(2-chloroacetyl)phenyl]ethan-1-one (CAS 1713-16-2)
- 7-Chloro-2-(3-chloropropyl)-2H-pyrazolo[4,3-d]pyrimidine (CAS 923283-13-0)
- 7-Chloro-6-(2-chloroethyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 62053-05-8)
- 5-Chloro-1-benzothiophene-2-carbonyl chloride (CAS 13771-97-6)
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Recommended Standards
- 3-Amino-6-bromo-N-methylpyrazine-2-carboxamide (CAS 146940-37-6)
- 5-Bromo-n-methoxypyridine-2-carboxamide (CAS 1493579-62-6)
- 2,4-Dichloro-8-fluoroquinolin-3-amine (CAS 1447960-18-0)
- Methyl 4-bromo-6-methylpyrimidine-2-carboxylate (CAS 1508102-01-9)
- 6-Chloro-2-methylquinoline-3-carboxylic acid ethyl ester (CAS 114858-39-8)
- 7,7-Dimethylspiro[3.5]nonan-2-one (CAS 2384680-04-8)
- (R)-Methyl 2-(((benzyloxy)carbonyl)amino)-2-(4-oxocyclohexyl)acetate (CAS 1384268-84-1)
- 2-Chloro-5-methylfuro[2,3-d]pyrimidine (CAS 1030377-49-1)
- 6-Hydroxy-5-phenylnicotinic acid (CAS 1214389-46-4)
- Glycohyocholic Acid (CAS 32747-08-3)
- 1-(Thieno[3,2-d]pyrimidin-4-yl)piperidine-4-carboxylic acid (CAS 910037-25-1)
- Ethyl 4-amino-2-oxabicyclo[2.1.1]Hexane-1-carboxylate hydrochloride (CAS 2375259-76-8)
- Remimazolam Impurity 5 (CAS 1276185-51-3)
- Semaglutide impurity 248 (CAS CATO-C4X-2226248)
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