Remimazolam Impurity 5 CAS 1276185-51-3
| CAS No. | 1276185-51-3 |
| Molecular Formula | C18H18BrN3O4 |
| Molecular Weight | 420.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Remimazolam Impurity 5 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Remimazolam Impurity 5 (CAS 1276185-51-3) is a certified pharmaceutical impurity reference standard with the molecular formula C18H18BrN3O4 and a molecular weight of 420.26 g/mol.
Based on its molecular formula C18H18BrN3O4, Remimazolam Impurity 5 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 420.26 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Remimazolam Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18BrN3O4 |
| Molecular Weight | 420.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Remimazolam Standards
- Remimazolam Impurity 2 (CAS 960305-91-3)
- Remimazolam Impurity 17 (CAS CATO-C4X-282317)
- Remimazolam Impurity 1 (CAS 1275616-59-5)
- Remimazolam Impurity 4 (CAS 308242-23-1)
- Remimazolam Impurity 6 (CAS 1449295-47-9)
- Remimazolam Impurity 1 (CAS CATO-C4X-28231)
- Remimazolam Impurity 12 (CAS 308243-65-4)
- Remimazolam Impurity 11 (CAS CATO-C4X-282311)
Recommended Standards
- 446286-06-2 2-(Methylsulfanyl)-4-(tributylstannyl)-1,3-thiazole DTXSID00676709 (CAS 446286-06-2)
- (3E,5E)-4-{[3,5-bis(trifluoromethyl)phenyl]amino}-6-(dimethylamino)-1,1,1-trifluorohexa-3,5-dien-2-one (CAS 338416-16-3)
- 7-[(E)-2-[(2,5-Difluorophenyl)methylidene]hydrazin-1-yl]-2,4-bis(trifluoromethyl)-1,8-naphthyridine (CAS 338962-14-4)
- N-(4-((4-bromophenyl)thio)phenyl)-2,6-difluorobenzamide (CAS 339104-51-7)
- Atenolol EP Impurity J HCI (CAS CATO-C4X-154923)
- Oseltamivir Impurity 245 (CAS 2765792-93-4)
- Glutathione Impurity 24 (CAS CATO-C4X-118524)
- n-(Cyclopentylmethyl)-3,4-difluoroaniline (CAS 1021125-72-3)
- n-(2-Aminoethyl)-1-phenylmethanesulfonamide (CAS 190257-50-2)
- 1-Benzyl-4-(5-fluoropyridin-3-yl)piperazine (CAS 1713160-01-0)
- (E)-N'-(4-(2,4-dimethylthiazol-5-yl)pyrimidin-2-yl)-N-hydroxyformimidamide (CAS 566149-74-4)
- 2-[(3-Methyloxetan-3-yl)methyl]isoindole-1,3-dione (CAS 153004-74-1)
- (3-Imidazol-1-yl-propyl)-(5-methyl-thiophen-2-ylmethyl)-amine (CAS 799262-41-2)
- Semaglutide impurity 29 (CAS CATO-C4X-222629)
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