3-Chlorothiophene-2-carboxamide CAS 147123-68-0
| CAS No. | 147123-68-0 |
| Molecular Formula | C5H4ClNOS |
| Molecular Weight | 161.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-Chlorothiophene-2-carboxamide is closely related to an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-Chlorothiophene-2-carboxamide (CAS 147123-68-0), molecular formula C5H4ClNOS and molecular weight 161.61 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Chlorothiophene-2-carboxamide (C5H4ClNOS) is characterized by an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-Chlorothiophene-2-carboxamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C5H4ClNOS |
| Molecular Weight | 161.61 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chlorothiophene Standards
- 4-Chlorothiophene-3-carboxamide (CAS 1174537-09-7)
- 4-Chlorothiophene-2-carboxamide (CAS 176203-88-6)
- 5-Chlorothiophene-3-carboxamide (CAS 189330-09-4)
- 2-Chlorothiophene-3-carboxamide (CAS 189330-14-1)
- 4-Chlorothiophene-2-boronic acid (CAS 1133931-02-8)
- 5-Chlorothiophene-3-boronic acid (CAS 199659-23-9)
- 4-Chlorothiophene-2-carboximidamide (CAS 1361003-73-7)
- 2-Acetyl-3-chlorothiophene (CAS 89581-82-8)
Recommended Standards
- 5-Amino-2-chloropyrimidine-4(3H)-thione (CAS 14623-59-7)
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- 3-Amino-5-chloropyrazine-2(1H)-thione (CAS 1801693-88-8)
- 3-Chloro-5-(methylthio)-1,2,4-triazine (CAS 1247802-89-6)
- Tetrakis[N-tetrachlorophthaloyl-(S)-tert-leucinato]dirhodiumBis(ethylAcetate)Adduct (CAS 2001054-65-3)
- 2-Chloro-1-(2,4,5-Trifluorophenyl)Ethanone (CAS 129604-31-5)
- 2-bromo-6-ethoxy-4-formylphenyl benzoate (CAS 431935-02-3)
- (1-Ethyl-1H-pyrazol-3-yl)methanesulfonyl chloride (CAS 1707395-88-7)
- 5-(3-Fluorophenyl)-3-(4-methoxyphenyl)-1H-1,2,4-triazole (CAS 1209648-85-0)
- 5-Chloro-2-(2,6-dichloro-4-fluorophenyl)-4-(4-methoxyphenoxy)-2,3-dihydropyridazin-3-one (CAS 672951-52-9)
- Dimethyl 5-(m-tolyl)-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate 2-oxide (CAS 339113-52-9)
- N-Methyl-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanamine (CAS 1171893-98-3)
- S-(2-Acetamidoethyl) O,O-dimethyl phosphorodithioate (CAS 13265-60-6)
- D-Ala28-Tirzepatide (CAS CATO-CPTD788906)
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