(1S,2R,5S)-Lamivudine Impurity 36 CAS 147126-72-5
| CAS No. | 147126-72-5 |
| Molecular Formula | C18H27N3O4S |
| Molecular Weight | 381.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of (1S,2R,5S)-Lamivudine Impurity 36 (C18H27N3O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
(1S,2R,5S)-Lamivudine Impurity 36 (CAS 147126-72-5) is a certified pharmaceutical impurity reference standard with the molecular formula C18H27N3O4S and a molecular weight of 381.49 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures (1S,2R,5S)-Lamivudine Impurity 36 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H27N3O4S |
| Molecular Weight | 381.49 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Recommended Standards
- ent-Lamivudine (1S,2R,5S)-5-Methyl-2-isopropylcyclohexyl Ester (CAS 147126-74-7)
- (2R,5R)-Lamivudine Impurity 37 (CAS 147126-80-5)
- (2R,5S)-Lamivudine Impurity 33 (CAS 147027-10-9)
- Lamivudine Impurity 45 (CAS CATO-C4X-119445)
- Cefprozil Impurity 49 (CAS CATO-C4X-149249)
- Indisetron Impurity 2 (CAS CATO-C4X-12512)
- N-Nitroso Ranolazine Impurity 14 (CAS CATO-C4X-102614)
- 2-(Bromomethyl)-1,3-difluoro-5-methylbenzene (CAS 1337606-87-7)
- 2-(1H-Imidazol-5-yl)cyclopentanamine (CAS 929102-06-7)
- 2-Cyano-3-[1-(4-fluorophenyl)-2,5-dimethyl-1h-pyrrol-3-yl]prop-2-enoic acid (CAS 733030-69-8)
- (4,5-Dimethylpyridin-2-yl)methanamine (CAS 1159830-12-2)
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- 2-(Bromomethyl)-1,3,4-trichlorobenzene (CAS 4960-48-9)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com