Azilsartan Impurity 5 CAS 147404-76-0
| CAS No. | 147404-76-0 |
| Molecular Formula | C25H23N3O4 |
| Molecular Weight | 429.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Azilsartan Impurity 5.
As a process- or degradation-related impurity, Azilsartan Impurity 5 (CAS 147404-76-0, C25H23N3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Azilsartan Impurity 5 (C25H23N3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Azilsartan Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H23N3O4 |
| Molecular Weight | 429.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 3 |
Related Azilsartan Standards
- Azilsartan Impurity N2 (CAS 1675221-59-6)
- Azilsartan Impurity 175 (CAS CATO-C4X-1096175)
- Azilsartan Impurity 3 (CAS CATO-C4X-10963)
- Azilsartan Impurity 32 (CAS CATO-C4X-109632)
- Azilsartan Impurity 7 (CAS 1397836-49-5)
- Azilsartan Impurity 14 (CAS 1442400-68-1)
- Azilsartan Impurity 118 (CAS CATO-C4X-1096118)
- Azilsartan impurity 150 (CAS CATO-C4X-1096150)
Recommended Standards
- Nivasorexant (CAS 1435480-40-2)
- Cefotaxime Impurity 17 (CAS CATO-C4X-120117)
- N-Cyclopentyl-2-((6-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-4-oxo-4H-pyran-3-yl)oxy)acetamide (CAS 898417-61-3)
- Ceftizoxime Open-ring Ethyl Ester (CAS CATO-C4X-179332)
- Phloroglucinol Impurity 65 (CAS CATO-C4X-221765)
- Avibactam Impurity 89 (CAS 1171080-45-7)
- Quetiapine EP Impurity H (CAS 1076199-40-0)
- 5-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole, 97% (CAS 478828-53-4)
- 2-(Hydroxymethyl)-5-methoxypyridin-4(1h)-one (CAS 6323-21-3)
- N-(4-(4-(Bis(2-chloroethyl)amino)phenoxy)butyl)acridin-9-amine (CAS 130031-47-9)
- N-Benzyl-2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS 65962-88-1)
- 3-Chloro-4-((3,4-dichlorobenzyl)oxy)-5-ethoxybenzaldehyde (CAS 428490-70-4)
- n-Ethyl-3-methyl-N-(pyrrolidin-3-yl)butanamide (CAS 1178703-36-0)
- Semaglutide Impurity 115 (CAS CATO-C4X-2226115)
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