Hydroxychloroquine EP Impurity D CAS 1476-52-4
| CAS No. | 1476-52-4 |
| Molecular Formula | C16H22ClN3 |
| Molecular Weight | 291.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Hydroxychloroquine EP Impurity D is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Hydroxychloroquine EP Impurity D (CAS 1476-52-4) is a certified pharmaceutical impurity reference standard with the molecular formula C16H22ClN3 and a molecular weight of 291.82 g/mol.
Hydroxychloroquine EP Impurity D (C16H22ClN3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Hydroxychloroquine EP Impurity D under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H22ClN3 |
| Molecular Weight | 291.82 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine Impurity 94 (CAS CATO-C4X-183594)
- Hydroxychloroquine Impurity 29 (CAS CATO-C4X-183529)
- Hydroxychloroquine impurity 85 (CAS CATO-C4X-183585)
- Hydroxychloroquine Impurity 45 (CAS CATO-C4X-183545)
- Hydroxychloroquine Impurity 3 (CAS 137433-25-1)
- Hydroxychloroquine EP Impurity C (CAS 4298-15-1)
- Hydroxychloroquine Impurity 73 (CAS CATO-C4X-183573)
- Hydroxychloroquine Impurity 75 (CAS 100713-49-3)
Recommended Standards
- 2-Chloro-5-((naphthalen-2-ylthio)methyl)thiazole (CAS 866039-40-9)
- (2Z)-n-[(3-chlorophenyl)methoxy]-1,7,7-trimethylbicyclo[2.2.1]heptan-2-imine (CAS 946386-36-3)
- n-((1,4-Dithian-2-yl)methyl)-1-(2-chloro-6-fluorophenyl)methanamine (CAS 1384649-96-0)
- 1-(4-Chlorophenyl)-2-(1-(cyclopropylmethyl)piperidin-4-yl)ethanone (CAS 144068-31-5)
- Vancomycin EP Impurity J (CAS 2416251-24-4)
- Eribulin Impurity 11 (CAS CATO-C4X-265011)
- Nintedanib Impurity 141 (CAS CATO-C4X-1814141)
- N-(2-Butoxybenzyl)-3-chloro-4-methoxyaniline (CAS 1040685-78-6)
- Pimethixene (CAS 314-03-4)
- 4-Chloro-6-(tetrahydro-2H-pyran-4-yl)pyrimidin-2-amine (CAS 1252555-21-7)
- Cariprazine Impurity 53 (CAS CATO-C4X-240853)
- 2-Chloro-N-(2,3,4,5,6-pentamethylphenyl)acetamide (CAS 64503-43-1)
- 5-Bromo-N,N-diethylpyrazin-2-amine (CAS 959238-87-0)
- Osteogenic Growth Peptide (10-14) (CAS 105250-85-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com