Niraparib Impurity 42 CAS 1476776-92-7
| CAS No. | 1476776-92-7 |
| Molecular Formula | C28H36N4O3 |
| Molecular Weight | 476.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Niraparib Impurity 42 (C28H36N4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Niraparib Impurity 42 (CAS 1476776-92-7) is a certified pharmaceutical impurity reference standard with the molecular formula C28H36N4O3 and a molecular weight of 476.61 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H36N4O3 |
| Molecular Weight | 476.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Nitrogen Atoms | 4 |
Related Niraparib Standards
- Niraparib Impurity 43 (CAS CATO-C4X-232943)
- Niraparib Impurity 37 (CAS CATO-C4X-232937)
- Niraparib Impurity 67 (CAS CATO-C4X-232967)
- Niraparib Impurity N19 (CAS 1038916-08-3)
- Niraparib Impurity 46 (CAS CATO-C4X-232946)
- Niraparib Impurity 41 (CAS CATO-C4X-232941)
- Niraparib Impurity 50 (CAS CATO-C4X-232950)
- Niraparib Impurity 38 (CAS CATO-C4X-232938)
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