1-(Chloromethoxy)-4-nitrobenzene CAS 14790-63-7
| CAS No. | 14790-63-7 |
| Molecular Formula | C7H6ClNO3 |
| Molecular Weight | 187.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 1-(Chloromethoxy)-4-nitrobenzene (CAS 14790-63-7), a certified reference material (molecular formula C7H6ClNO3, MW 187.58 g/mol) for analytical method development and quality control.
The molecular framework of 1-(Chloromethoxy)-4-nitrobenzene (C7H6ClNO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6ClNO3 |
| Molecular Weight | 187.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloromethoxy Standards
- 1-(Chloromethoxy)-3-nitrobenzene (CAS 1357626-48-2)
- 1-(Chloromethoxy)-2-nitrobenzene (CAS 14790-64-8)
- 1,4-Bis(chloromethoxy)butane (CAS 13483-19-7)
- (2-(Chloromethoxy)ethoxy)benzene (CAS 102331-29-3)
- 1-((Chloromethoxy)methyl)-4-methoxybenzene (CAS 88023-78-3)
- 1-(Chloromethoxy)-4-ethoxybenzene (CAS 847186-02-1)
- 1-(2-(Chloromethoxy)ethyl)-4-fluorobenzene (CAS 182949-79-7)
- 2-(Chloromethoxy)benzamide (CAS 1512203-12-1)
Recommended Standards
- Methyl 3-Amino-6-chloropyrazine-2-carboxylate (CAS 1458-03-3)
- 4-Chloro-3-nitrobenzene-1,2-diamine (CAS 144729-44-2)
- 2-Amino-5-chloro-4-methyl-3-nitropyridine (CAS 148612-17-3)
- 6-Chloro-4-(hydroxymethyl)nicotinic acid (CAS 1440526-57-7)
- 2-Methoxy-4,5-dimethylbenzoyl chloride (CAS 1245531-38-7)
- 2,4-Bis(difluoromethoxy)aniline (CAS 22236-14-2)
- (1-(((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)methyl)cyclopropyl)methanol (CAS 2771459-87-9)
- (1-((1H-Indol-3-yl)methyl)-4-(2-chlorophenyl)piperidin-4-yl)methanol (CAS 925218-05-9)
- 3-(4-(Trifluoromethoxy)phenyl)picolinic acid (CAS 1261561-96-9)
- Nilotinib Impurity 11 (CAS CATO-C4X-125611)
- Methyl 3-methylimidazo[1,5-a]pyrazine-1-carboxylate (CAS 1341040-37-6)
- (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-ureidophenyl)propanoic acid (CAS 324017-23-4)
- 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetohydrazide (CAS 2096330-17-3)
- Semaglutide impurity 255 (CAS CATO-C4X-2226255)
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