Terbutaline Impurity 27 CAS 147942-88-9
| CAS No. | 147942-88-9 |
| Molecular Formula | C22H20O3 |
| Molecular Weight | 332.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Terbutaline Impurity 27.
Terbutaline Impurity 27 (CAS 147942-88-9) is a certified pharmaceutical impurity reference standard with the molecular formula C22H20O3 and a molecular weight of 332.39 g/mol.
Structurally, Terbutaline Impurity 27 (C22H20O3) contains a steroid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 332.39 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H20O3 |
| Molecular Weight | 332.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
Related Terbutaline Standards
- Terbutaline Impurity N24 (CAS 27628-06-4)
- Terbutaline Impurity 12 (CAS 22877-01-6)
- Terbutaline Impurity 15 (CAS 3886-19-9)
- Terbutaline Impurity 22 (CAS 50841-47-9)
- Terbutaline Impurity 35 (CAS 28924-21-2)
- Terbutaline Impurity 5 (CAS 21766-81-4)
- Terbutaline Impurity 37 (CAS 28917-43-3)
- Terbutaline Impurity 88 (CAS CATO-C4X-118388)
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