Terbutaline Impurity 5 CAS 21766-81-4
| CAS No. | 21766-81-4 |
| Molecular Formula | C22H20O3 |
| Molecular Weight | 332.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Terbutaline Impurity 5.
As a process- or degradation-related impurity, Terbutaline Impurity 5 (CAS 21766-81-4, C22H20O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Terbutaline Impurity 5 (C22H20O3) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Terbutaline Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H20O3 |
| Molecular Weight | 332.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
Related Terbutaline Standards
- Terbutaline Impurity N24 (CAS 27628-06-4)
- Terbutaline Impurity 12 (CAS 22877-01-6)
- Terbutaline Impurity 15 (CAS 3886-19-9)
- Terbutaline Impurity 22 (CAS 50841-47-9)
- Terbutaline Impurity 27 (CAS 147942-88-9)
- Terbutaline Impurity 35 (CAS 28924-21-2)
- Terbutaline Impurity 37 (CAS 28917-43-3)
- Terbutaline Impurity 88 (CAS CATO-C4X-118388)
Recommended Standards
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