4-(2,2-Difluoroethoxy)-3-trifluoromethylbenzaldehyde CAS 1486100-65-5
| CAS No. | 1486100-65-5 |
| Molecular Formula | C10H7F5O2 |
| Molecular Weight | 254.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(2,2-Difluoroethoxy)-3-trifluoromethylbenzaldehyde is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-(2,2-Difluoroethoxy)-3-trifluoromethylbenzaldehyde (CAS 1486100-65-5), molecular formula C10H7F5O2 and molecular weight 254.15 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(2,2-Difluoroethoxy)-3-trifluoromethylbenzaldehyde (C10H7F5O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7F5O2 |
| Molecular Weight | 254.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
Related Difluoroethoxy Standards
- 3-(2,2-Difluoroethoxy)-2-naphthoic acid (CAS 1183017-57-3)
- 4-(2,2-Difluoroethoxy)benzene-1-sulfonyl chloride (CAS 954369-07-4)
- 2-(2,2-difluoroethoxy)-5-methanesulfonylaniline (CAS 1556789-81-1)
- 2-(2,2-Difluoroethoxy)benzyl bromide (CAS 1179229-29-8)
- 4-(2,2-Difluoroethoxy)benzyl bromide (CAS 1184195-23-0)
- 2-(2,2-difluoroethoxy)pyridine-3-sulfonyl chloride (CAS 1565428-15-0)
- 3-(3-(2,2-Difluoroethoxy)-4-nitro-1H-pyrazol-1-yl)propan-1-amine (CAS 1855945-09-3)
- 2-[[4-(2,2-Difluoroethoxy)benzoyl]amino]acetic acid (CAS 921623-05-4)
Recommended Standards
- 1-(3-Ethoxy-4,5-difluorophenyl)-2,2,2-trifluoroethan-1-one (CAS 1443327-55-6)
- 3-(3,4-Difluorophenyl)-4,4,4-trifluorobutanoic acid (CAS 1508417-38-6)
- 1-(2-Ethoxy-3,5-difluorophenyl)-2,2,2-trifluoroethan-1-one (CAS 1443304-12-8)
- 2-(4-Bromophenyl)thiophen-3-amine (CAS 183677-02-3)
- 3-Iodo-4-pentylbenzoic acid (CAS 1131588-17-4)
- Ethyl 2-(4,4-dimethyl-2-oxocyclohexyl)-2-oxoacetate (CAS 412019-00-2)
- 3-(2-Chlorophenyl)-N-{[3-(4-methoxyphenyl)-1,2-oxazol-5-yl]methyl}-1,2-oxazole-5-carboxamide (CAS 338750-11-1)
- 5-Methyl-7-phenyl-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 133533-72-9)
- {[1-(3-methylphenyl)-1H-pyrazol-4-yl]methyl}amine hydrochloride (CAS 1049764-99-9)
- 4-Methyl-5-propylisoxazol-3-amine (CAS 1207175-25-4)
- 1-[(4-tert-Butylphenyl)methyl]-6-phenyl-1,2-dihydropyridin-2-one (CAS 400076-11-1)
- (R,R)-Efinaconazole Epoxide (CAS 135270-13-2)
- Sulfide (CAS 18496-25-8)
- Semaglutide Impurity 7 (CAS CATO-C4X-22267)
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