Dorzolamide Impurity 8 CAS 148810-83-7
| CAS No. | 148810-83-7 |
| Molecular Formula | C10H13NO3S2 |
| Molecular Weight | 259.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Dorzolamide Impurity 8 (CAS 148810-83-7), a pharmacopoeial impurity reference standard (molecular formula C10H13NO3S2, MW 259.35 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Dorzolamide Impurity 8 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 259.35 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H13NO3S2 |
| Molecular Weight | 259.35 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Dorzolamide Standards
- Dorzolamide Impurity 20 (CAS 147086-83-7)
- Dorzolamide Impurity 10 (CAS CATO-C4X-122810)
- Dorzolamide Impurity 9 (CAS CATO-C4X-12289)
- Dorzolamide Impurity 12 (CAS 403848-01-1)
- Dorzolamide Impurity 7 (CAS CATO-C4X-12287)
- Dorzolamide EP Impurity D (CAS 154154-90-2)
- Dorzolamide Impurity 8 (CAS 120279-26-7)
- Dorzolamide Impurity 4 (CAS 154802-22-9)
Recommended Standards
- Tofacitinib Impurity 11 (CAS 2227197-38-6)
- Famotidine EP Impurity D (CAS 76824-16-3)
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- CC-223, >98% (HPLC) (CAS 1228013-30-6)
- Sildenafil Impurity 75 (CAS 2253964-66-6)
- Methyl 4,4-difluoro-3-oxobutanoate (CAS 89129-66-8)
- Antifreeze Polypeptide 6 (winter flounder) trifluoroacetate salt (CAS 122604-16-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com