Atogepant Impurity 8 CAS 1488327-11-2
| CAS No. | 1488327-11-2 |
| Molecular Formula | C17H21F3N2O3 |
| Molecular Weight | 358.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Atogepant Impurity 8.
Atogepant Impurity 8 (CAS 1488327-11-2) is a certified pharmaceutical impurity reference standard with the molecular formula C17H21F3N2O3 and a molecular weight of 358.36 g/mol.
Atogepant Impurity 8 (C17H21F3N2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H21F3N2O3 |
| Molecular Weight | 358.36 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Atogepant Standards
- Atogepant Impurity 47 (CAS CATO-C4X-328547)
- Atogepant Impurity 48 (CAS CATO-C4X-328548)
- Atogepant Impurity 49 (CAS CATO-C4X-328549)
- Atogepant Impurity 50 (CAS CATO-C4X-328550)
- Atogepant Impurity 51 (CAS CATO-C4X-328551)
- Atogepant Impurity 74 (CAS CATO-C4X-328574)
- Atogepant Impurity 9 (CAS 1456803-43-2)
- Atogepant Impurity 13 (CAS 1456803-65-8)
Recommended Standards
- Ubrogepant Impurity 29 (CAS CATO-C4X-340229)
- Ubrogepant Impurity 30 (CAS CATO-C4X-340230)
- Ubrogepant Impurity 31 (CAS CATO-C4X-340231)
- 2,3-Dimethyl-3-buten-2-ol (CAS 10473-13-9)
- Candesartan impurity 4 (CAS CATO-C4X-15724)
- Trimebutine impurity 23 (CAS CATO-C4X-185823)
- Fluralaner Impurity 8 (CAS CATO-C4X-21808)
- 5-(Methoxycarbonyl)-1h-indole-2-carboxylicacid (CAS 681288-76-6)
- 4-Ethoxy-N-(6-fluorobenzo[d]thiazol-2-yl)benzamide (CAS 476297-76-4)
- Sugammadex Sodium Impurity Org199010-1 (CAS CATO-C4X-190675)
- 2-([1,1'-Biphenyl]-4-yloxy)-1-cyclopropylethan-1-amine (CAS 1379811-40-1)
- 1354960-67-0 5-Chloro-2,4-difluoro-N-(methylsulfonyl)benzamide (CAS 1354960-67-0)
- Methyl 4-(2,5-Dimethoxyphenyl)-2,4-dioxobutanoate (CAS 70935-15-8)
- Semaglutide impurity 258 (CAS CATO-C4X-2226258)
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