Venlafaxine Impurity 22 CAS 149289-29-2
| CAS No. | 149289-29-2 |
| Molecular Formula | C14H21NO2 |
| Molecular Weight | 235.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Venlafaxine Impurity 22 (CAS 149289-29-2, C14H21NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Venlafaxine Impurity 22 (C14H21NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 235.32 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H21NO2 |
| Molecular Weight | 235.32 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 1 |
Related Venlafaxine Standards
- Venlafaxine Impurity 5 (CAS 1346600-77-8)
- Venlafaxine Impurity 37 (CAS CATO-C4X-143437)
- Venlafaxine Impurity 16 (CAS 6547-53-1)
- Venlafaxine Impurity 61 (CAS 2641915-09-3)
- Venlafaxine Impurity 79 (CAS 80526-53-0)
- Venlafaxine impurity 01 (CAS 131801-69-9)
- Venlafaxine Impurity 34 (CAS 93413-76-4)
- Venlafaxine Impurity 73 (CAS 1574357-68-8)
Recommended Standards
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- Verapamil Impurity 49 (CAS CATO-C4X-177849)
- Belumosudil Impurity N7 (CAS 911419-33-5)
- Indapamide Impurity 41 (CAS 85392-00-3)
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- Ethyl 4-Phenylpyrazole-3-carboxylate (CAS 6963-62-8)
- 2-(5-Bromo-3-methyl-2-thienyl)ethylamine (CAS 1784018-54-7)
- 2-(3,5-Dibromopyridin-2-yl)acetic acid (CAS 1214352-71-2)
- Milrinone Impurity 21 (CAS 2497745-31-8)
- (4-Amino-3-nitrophenyl)(4-methylpiperazin-1-yl)methanone (CAS 1160994-45-5)
- N-(5-Thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide (CAS 391864-20-3)
- Semaglutide (CAS CATO-C4X-2226105)
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