4-(4-(Trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid CAS 1495970-13-2
| CAS No. | 1495970-13-2 |
| Molecular Formula | C11H7F3N2O2 |
| Molecular Weight | 256.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-(4-(Trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid (CAS 1495970-13-2), molecular formula C11H7F3N2O2 and molecular weight 256.18 g/mol, is a CATO reference standard with documented purity and traceability.
4-(4-(Trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid (C11H7F3N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 4-(4-(Trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H7F3N2O2 |
| Molecular Weight | 256.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Trifluoromethyl Standards
- 3-[4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]phenyl]-2E-propenoic acid (CAS 1002328-38-2)
- 3-(3-(Trifluoromethyl)-1H-pyrazol-5-yl)benzoic acid (CAS 1031417-48-7)
- 3-(4-(TRIFLUOROMETHYL)PHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID (CAS 1038398-68-3)
- 3-[2-(trifluoromethyl)phenyl]-1H-pyrazole-5-carboxylic acid (CAS 1038770-76-1)
- N-(5-(Trifluoromethyl)isoxazol-3-yl)benzamide (CAS 110235-11-5)
- 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylic acid (CAS 1143521-43-0)
- 3-[5-(trifluoromethyl)-1h-pyrazol-1-yl]benzoic acid (CAS 1152530-82-9)
- 5-[2-(Trifluoromethyl)phenyl]-1h-pyrazole-4-carboxylic acid (CAS 1152539-99-5)
Recommended Standards
- 2-Hydrazinyl-3,5-dinitrobenzohydrazide (CAS 1432436-41-3)
- 5-(4-Bromophenyl)-3-methylpentan-1-amine (CAS 1496611-24-5)
- 1-Phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (CAS 142818-01-7)
- n-(4-Bromo-3-methylbenzyl)-2-methylpropan-1-amine (CAS 1506566-98-8)
- (3-Chloro-4-methoxyphenyl)(1-(trifluoromethyl)spiro[benzo[b]pyrrolo[1,2-d][1,4]oxazine-4,4'-piperidin]-1'-yl)methanone (CAS 1433633-45-4)
- 2-Bromo-5-isopropylthiophene (CAS 29488-23-1)
- 2-(Chloromethyl)-4-(difluoromethyl)-5-methylpyridine-3-carboxylic acid (CAS 1361902-02-4)
- 2-(3-Fluorophenyl)pyrazine (CAS 1286755-19-8)
- tert-Butyl 1-oxo-4-phenyl-2,8-diazaspiro[4.5]decane-8-carboxylate (CAS 897670-78-9)
- (E)-4-(3-(2,4-dimethoxyphenyl)acryloyl)phenyl 3-nitrobenzoate (CAS 331461-70-2)
- Ethyl 2-(2-chloropyridin-4-yl)acetate (CAS 937236-73-2)
- N-(3-Amino-4-chlorophenyl)-2-(4-isopropylphenoxy)-propanamide (CAS 1020055-74-6)
- 1,2-Bis(phenylphosphino)ethane, min. 95% (10wt% in hexanes) (CAS 18899-64-4)
- Semaglutide Impurity 139 (CAS CATO-C4X-2226139)
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