Pyronaridine Impurity 8 CAS 14969-40-5
| CAS No. | 14969-40-5 |
| Molecular Formula | C13H18N2O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Pyronaridine Impurity 8 (CAS 14969-40-5, C13H18N2O2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Pyronaridine Impurity 8 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 270.76 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Pyronaridine Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H18N2O2 HCl |
| Molecular Weight | 270.76 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Pyronaridine Standards
- Pyronaridine D4 (CAS 1186026-25-4)
- Pyronaridine Impurity 2 (CAS 1422180-92-4)
- Pyronaridine Impurity 14 (CAS 1596337-67-5)
- Pyronaridine Impurity 13 (CAS 1596337-68-6)
- Pyronaridine Impurity 10 (CAS 6626-40-0)
- Pyronaridine (CAS 74847-35-1)
- Pyronaridine Tetraphosphate (CAS 76748-86-2)
- Pyronaridine Impurity 7 (CAS 81935-60-6)
Recommended Standards
- Cefprozil Impurity 30 (CAS CATO-C4X-149230)
- Vardenafil Impurity 57 (CAS CATO-C4X-101757)
- Dabigatran Impurity 133 (CAS CATO-C4X-1089133)
- 4,5-Dichloro-2-methoxybenzaldehyde (CAS 883532-73-8)
- 1',2'-dihydrospiro[piperidine-4,3'-pyrrolo[2,3-b]pyridine]-2'-one (CAS 884049-52-9)
- 4-Hydroxy-2-(methylsulfonamido)benzoic acid (CAS 1243282-41-8)
- 1-[2-(oxan-2-yloxy)ethyl]-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 956907-34-9)
- (S)-2-methylpiperidine-2-carboxylic acid hydrochloride (CAS 123053-40-7)
- 3-(2,6-Dichlorophenyl)propanal (CAS 1057670-91-3)
- Semaglutide Impurity 187 (CAS CATO-C4X-2226187)
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