N-nitroso-fluoxetine CAS 150494-06-7
| CAS No. | 150494-06-7 |
| Molecular Formula | C17H17F3N2O2 |
| Molecular Weight | 338.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
N-nitroso-fluoxetine (C17H17F3N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, N-nitroso-fluoxetine (CAS 150494-06-7, C17H17F3N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), N-nitroso-fluoxetine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H17F3N2O2 |
| Molecular Weight | 338.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- N-Nitroso-Sertraline-D3 (CAS CATO-C4X-134454)
- N-Nitroso Sertraline D3 (CAS CATO-C4X-134456)
- N3-Nitroso Abrocitinib (CAS CATO-C4X-28845)
- N-Nitroso-Nadolol (CAS 134720-06-2)
- N-Nitroso Dehydro Desloratadine (CAS CATO-C4X-143058)
- N-Nitroso (S) - Demethylcitalopram (CAS CATO-C4X-110971)
- N-Nitroso Citalopram (CAS CATO-C4X-110974)
- N-Nitroso Desloratadine (CAS 1246819-22-6)
Recommended Standards
- Rivaroxaban impurity 169 (CAS CATO-C4X-1090169)
- Fluoxetine Impurity 50 (CAS CATO-C4X-135250)
- 321553-59-7 KS-00001VDB N-(2-methoxyphenyl)-3-nitro-4-(1H-pyrazol-1-yl)benzenecarboxamide (CAS 321553-59-7)
- Cariprazine Impurity 44 (CAS CATO-C4X-240844)
- Gatifloxacin Impurity 16 (CAS 855997-06-7)
- Aprepitant impurity 54 HCl (CAS CATO-C4X-114154)
- Nintedanib Impurity 45 (CAS 70380-66-4)
- (E)-2-cyano-N-cyclohexyl-3-(3-hydroxyphenyl)acrylamide (CAS 351893-99-7)
- 5-Acetylpyrimidine-4-carboxylic acid (CAS 133510-36-8)
- 6-Methoxy-2-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline (CAS 1116230-95-5)
- D-Norepinephrine (CAS 149-95-1)
- 2-(3-(4-Methoxyphenyl)-1H-pyrazol-1-yl)acetic acid (CAS 959584-25-9)
- 2-Methyl-5-(trifluoromethyl)nicotinic acid (CAS 1211581-65-5)
- Peptide Impurity 82 (CAS 10491-78-8)
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