Nintedanib Impurity 45 CAS 70380-66-4
| CAS No. | 70380-66-4 |
| Molecular Formula | C9H11ClO2 |
| Molecular Weight | 186.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Nintedanib Impurity 45 (CAS 70380-66-4), a pharmacopoeial impurity reference standard (molecular formula C9H11ClO2, MW 186.64 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C9H11ClO2, Nintedanib Impurity 45 contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 186.64 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nintedanib Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H11ClO2 |
| Molecular Weight | 186.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity 39 (CAS 3395-81-1)
- Nintedanib Impurity 44 (CAS 3395-80-0)
- Nintedanib Impurity 67 (CAS 40872-87-5)
- Nintedanib Impurity 184 (CAS 873376-89-7)
- Nintedanib Impurity 38 (CAS 58378-33-9)
- Nintedanib Impurity 42 (CAS 2186-92-7)
- Nintedanib Impurity 43 (CAS 59276-28-7)
- Nintedanib Impurity 66 (CAS 707-07-3)
Recommended Standards
- 1-(3-Chloro-2-methylpropyl)-2-fluoro-benzene (CAS 101975-64-8)
- 1-(1-Chlorobutan-2-yl)-4-fluorobenzene (CAS 1225846-66-1)
- Verapamil Impurity 27 (CAS 7306-46-9)
- 2-(3-Chloropropyl)-4-fluoro-1-methylbenzene (CAS 1339775-79-9)
- Dutaverine Impurity 34 HCl (CAS CATO-C4X-243534)
- Venetoclax Impurity 111 (CAS CATO-C4X-2495111)
- Brimonidine Impurity 21 (CAS 1378255-24-3)
- (2S)-2-Amino-N-((1-benzylpiperidin-3-yl)methyl)propanamide (CAS 1354029-72-3)
- D-(+)-2-Phosphoglyceric Acid Sodium Hydrate (CAS 70195-25-4)
- 1,4-Bis[3,4-dihydro-2(1H)-quinolinon-7-oxy]butane-d8 (CAS 1346599-01-6)
- 8-Bromo-2-chloropyrido[3,4-b]pyrazin-7-ol (CAS 2377496-00-7)
- Pyrenecarboxaldehyde (CAS 68967-09-9)
- 5-(Azidomethyl)-3,3-difluorodihydro-2(3H)-furanone (CAS 189136-13-8)
- Renin Inhibitor Peptide (CAS 50410-01-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com