2-hydroxy-5-methyl-1,3-thiazole-4-carboxylic acid CAS 1505865-51-9
| CAS No. | 1505865-51-9 |
| Molecular Formula | C5H5NO3S |
| Molecular Weight | 159.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-hydroxy-5-methyl-1,3-thiazole-4-carboxylic acid (CAS 1505865-51-9), molecular formula C5H5NO3S and molecular weight 159.16 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-hydroxy-5-methyl-1,3-thiazole-4-carboxylic acid (C5H5NO3S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 2-hydroxy-5-methyl-1,3-thiazole-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5NO3S |
| Molecular Weight | 159.16 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1992 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related hydroxy Standards
- 4-hydroxy-5-methyl-1,3-thiazole-2-carboxylic acid (CAS 133833-94-0)
- 2-Hydroxy-4-methylthiazole-5-carboxylic acid (CAS 875237-46-0)
- 4-Hydroxy-5-methylisothiazole-3-carboxylic acid (CAS 716361-63-6)
- 3-Hydroxy-4-cyano (1H)Indazole (CAS 1000342-91-5)
- 3-Hydroxy-5-phenylpyrrole (CAS 100750-40-1)
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- 6-Hydroxy-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (CAS 1167056-72-5)
- 3-Hydroxy-N-methoxy-N-methylcyclobutane-1-carboxamide (CAS 1187595-64-7)
Recommended Standards
- Methyl 2-thioxo-2,3-dihydrooxazole-5-carboxylate (CAS 149432-34-8)
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- 4-Fluorobenzisoxazol-3(2H)-one (CAS 178747-83-6)
- [(2R)-5,5-dimethyloxolan-2-yl]methanamine (CAS 1426650-75-0)
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- 1-(Iodomethyl)-4-methylbenzene (CAS 4484-74-6)
- 9-(2-Propynyl)carbazole (CAS 4282-77-3)
- (2S,4R)-4-Acetoxypyrrolidine-2-carboxylic acid (CAS 46122-47-8)
- N5-(4-Aminophenyl)pyrimidine-2,5-diamine (CAS 869564-05-6)
- N1-(3-Pyridinylmethyl)-1,3-propanediamine (CAS 100553-71-7)
- 1-(2-Fluorophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 1152564-84-5)
- 5,7-Dimethoxycinnoline-3-carboxylic acid (CAS 929975-20-2)
- Des-Lys20(Side Chain)-Semaglutide (CAS CATO-C4X-2226280)
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