Brinzolamide Hydrochloride CAS 150937-43-2
| CAS No. | 150937-43-2 |
| Molecular Formula | C12H21N3O5S3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Brinzolamide Hydrochloride.
Brinzolamide Hydrochloride (CAS 150937-43-2) is a high-purity analytical reference standard with the molecular formula C12H21N3O5S3HCl and a molecular weight of 419.95 g/mol.
The molecular framework of Brinzolamide Hydrochloride (C12H21N3O5S3HCl) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Brinzolamide Hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H21N3O5S3 HCl |
| Molecular Weight | 419.95 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 3 |
Related Brinzolamide Standards
- Brinzolamide D5 (CAS 1217651-02-9)
- Brinzolamide Impurity 13 (CAS 138890-50-3)
- Brinzolamide Impurity 23 (CAS 138890-58-1)
- Brinzolamide (CAS 138890-62-7)
- Brinzolamide Impurity 19 (CAS 154127-19-2)
- Brinzolamide Impurity 17 (CAS 154127-41-0)
- Brinzolamide Impurity 14 (CAS 154127-42-1)
- Brinzolamide Impurity 18 (CAS 160982-13-8)
Recommended Standards
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- Phosphoric acid, polymer with .alpha.,.alpha.',.alpha.''-1,2,3-propanetriyltris[.omega.-hydroxypoly[oxy(methyl-1,2-ethanediyl)]] (CAS 68541-65-1)
- Amlodipine Impurity 143 (CAS CATO-C4X-1095143)
- 4-Amino-1-((2R,3S,4R,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (CAS 26563-01-9)
- 2-((6-Amino-9-butyl-9H-purin-8-yl)thio)acetamide (CAS 1387565-78-7)
- (S)-2-Chloro-N-cyclopropyl-N-(1-methylpyrrolidin-3-yl)acetamide (CAS 1354010-84-6)
- Methyl 4,5,6,7-tetrahydro-1H-benzo[d]imidazole-6-carboxylate (CAS 26785-89-7)
- Exenatide Acetate (CAS 141732-76-5)
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