2,2-Difluoromalonic acid CAS 1514-85-8

Purity 97%+In StockPharmaceutical Standards
CAS No.1514-85-8
Molecular FormulaC3H2F2O4
Molecular Weight140.04 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2,2-Difluoromalonic acid CAS 1514-85-8 chemical structure

Description

The occurrence of 2,2-Difluoromalonic acid is closely related to a carboxylic acid group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

2,2-Difluoromalonic acid (CAS 1514-85-8) is a high-purity analytical reference standard with the molecular formula C3H2F2O4 and a molecular weight of 140.04 g/mol.

The molecular framework of 2,2-Difluoromalonic acid (C3H2F2O4) is characterized by a carboxylic acid group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2,2-Difluoromalonic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC3H2F2O4
Molecular Weight140.04 g/mol
Purity97%+
StorageStore at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, ethanol, DMSO, water
StabilityHygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)2.0
CAS Registry Year (est.)1957
Halogen ContentF-containing

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