Flurbiprofen Impurity 154 CAS 1515573-52-0

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.1515573-52-0
Molecular FormulaC12H8BrF
Molecular Weight251.09 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Flurbiprofen Impurity 154 CAS 1515573-52-0 chemical structure

Description

Flurbiprofen Impurity 154 (CAS 1515573-52-0) is a certified pharmaceutical impurity reference standard with the molecular formula C12H8BrF and a molecular weight of 251.09 g/mol.

Flurbiprofen Impurity 154 (C12H8BrF) contains fluorine/bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC12H8BrF
Molecular Weight251.09 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)8.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1992
Halogen ContentF/Br-containing

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