5-fluoro-6-hydroxypyridine-3-carboxylic acid CAS 1526-16-5
| CAS No. | 1526-16-5 |
| Molecular Formula | C6H10FNO3 |
| Molecular Weight | 163.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
5-fluoro-6-hydroxypyridine-3-carboxylic acid (CAS 1526-16-5) is a high-purity analytical reference standard with the molecular formula C6H10FNO3 and a molecular weight of 163.15 g/mol.
5-fluoro-6-hydroxypyridine-3-carboxylic acid (C6H10FNO3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 5-fluoro-6-hydroxypyridine-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H10FNO3 |
| Molecular Weight | 163.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- 3-Methyl-9H-pyrido[3,4-b]indole (CAS 18203-06-0)
- 2-(4-(Benzyloxy)-3,5-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1255041-73-6)
- methyl 6-chloro-1H-indole-5-carboxylate (CAS 162100-83-6)
- 2-Amino-5-hydroxy-4-methoxybenzonitrile (CAS 1208903-74-5)
- Avibactam Impurity 21 (CAS 1416134-63-8)
- 4-Butyl-6-(3-(dimethylamino)acryloyl)-7-hydroxy-8-methyl-2h-chromen-2-one (CAS 1821457-39-9)
- Des-Pro31-Tirzepatide (CAS CATO-CPTD788943)
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