Fluocinolone Acetonide EP Impurity F CAS 1526-01-8
| CAS No. | 1526-01-8 |
| Molecular Formula | C24H33FO5 |
| Molecular Weight | 420.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Fluocinolone Acetonide EP Impurity F is closely related to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Fluocinolone Acetonide EP Impurity F (CAS 1526-01-8), a pharmacopoeial impurity reference standard (molecular formula C24H33FO5, MW 420.51 g/mol) used for the identification and quantification of trace impurities in APIs.
Fluocinolone Acetonide EP Impurity F (C24H33FO5) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H33FO5 |
| Molecular Weight | 420.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Fluocinolone Standards
- Fluocinolone Acetonide Impurity 43 (CAS 3802-45-7)
- Fluocinolone Acetonide Impurity N2 (CAS 3830-58-8)
- Fluocinolone Acetonide impurity 21 (CAS CATO-C4X-238121)
- Fluocinolone Acetonide impurity 22 (CAS CATO-C4X-238122)
- Fluocinolone Acetonide EP Impurity C (CAS 807-38-5)
- Fluocinolone Acetonide EP Impurity E (CAS 68352-03-4)
- Fluocinolone Acetonide Impurity 46 (CAS CATO-C4X-238146)
- Fluocinolone Acetonide EP Impurity B (CAS 65751-34-0)
Recommended Standards
- Ruxolitinib Impurity 69 (CAS 1236033-05-8)
- Halcinonide Impurity N1 (CAS 3093-36-5)
- Ruxolitinib Impurity 61 (CAS 1146629-80-2)
- N-(2-(Furan-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-1-(thiophen-2-yl)cyclopentane-1-carboxamide (CAS 1207023-31-1)
- Lifitegrast Impurity 114 (CAS CATO-C4X-2409114)
- Azithromycin impurity 60 (CAS CATO-C4X-100360)
- Emedastine Impurity 49 (CAS CATO-C4X-226749)
- (S)-2-Amino-3-((S)-2-oxopyrrolidin-3-yl)propanenitrile methanesulfonate (CAS 2755812-52-1)
- 16-Methyloctadecanoicacid (CAS 17001-28-4)
- N-(2-Amino-1,3-dioxoisoindolin-4-yl)acetamide (CAS 861017-69-8)
- Ethyl 8-(3-cyanophenyl)-8-oxooctanoate (CAS 951885-66-8)
- (3S,4S)-2,5-dioxotetrahydrofuran-3,4-diyl bis(4-methylbenzoate) (CAS 156835-63-1)
- 2-{3-oxo-2h,3h-[1,2,4]triazolo[4,3-a]pyridin-2-yl}acetonitrile (CAS 1016878-15-1)
- Semaglutide Impurity 11 (CAS CATO-C4X-222611)
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