Diclofenac Ethyl Ester (Aceclofenac EP Impurity C) CAS 15307-77-4
| CAS No. | 15307-77-4 |
| Molecular Formula | C16H15Cl2NO2 |
| Molecular Weight | 324.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Diclofenac Ethyl Ester (Aceclofenac EP Impurity C) (CAS 15307-77-4) is a certified pharmaceutical impurity reference standard with the molecular formula C16H15Cl2NO2 and a molecular weight of 324.20 g/mol.
Structurally, Diclofenac Ethyl Ester (Aceclofenac EP Impurity C) (C16H15Cl2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 324.20 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Diclofenac Ethyl Ester (Aceclofenac EP Impurity C) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H15Cl2NO2 |
| Molecular Weight | 324.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac Impurity 31 (CAS 1219112-85-2)
- Diclofenac-d4 Sodium Salt (phenyl-d4-acetic) (CAS 154523-54-3)
- Diclofenac Impurity 7 (CAS 69002-86-4)
- Diclofenac impurity 9 (CAS CATO-C4X-16149)
- Diclofenac impurity f (CAS 124426-56-8)
- Diclofenac sodium Impurity 37 (CAS 15308-01-7)
- Diclofenac EP Impurity F (CAS 560075-65-2)
- Diclofenac Impurity 23 (CAS CATO-C4X-105123)
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- 2-(2-Acetamidothiazol-4-yl)-N-(2,6-difluorobenzyl)acetamide (CAS 923675-71-2)
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