Diclofenac sodium Impurity 37 CAS 15308-01-7
| CAS No. | 15308-01-7 |
| Molecular Formula | C14H10Cl3NO |
| Molecular Weight | 314.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Diclofenac sodium Impurity 37 (CAS 15308-01-7) is a certified pharmaceutical impurity reference standard with the molecular formula C14H10Cl3NO and a molecular weight of 314.59 g/mol.
Structurally, Diclofenac sodium Impurity 37 (C14H10Cl3NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 314.59 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H10Cl3NO |
| Molecular Weight | 314.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac impurity f (CAS 124426-56-8)
- Diclofenac EP Impurity F (CAS 560075-65-2)
- Diclofenac Impurity 23 (CAS CATO-C4X-105123)
- Diclofenac Impurity 42 (CAS 944251-06-3)
- Diclofenac Impurity 44 (CAS 69002-85-3)
- Diclofenac Methyl Ester (Aceclofenac EP Impurity B) (CAS 15307-78-5)
- Diclofenac sodium Impurity 48 (CAS 66156-75-0)
- Diclofenac Related Compound 1 (CAS 928343-25-3)
Recommended Standards
- 5-Chloro-2-fluoro-4-isopropoxyphenylboronic acid pinacol ester (CAS 2121513-71-9)
- 3,5-Dichloro-N-[(3-chlorophenyl)methyl]benzamide (CAS 303144-96-9)
- Perospirone Impurity 13 (CAS CATO-C4X-245813)
- 2-Chloro-N-(2,4-dichlorophenyl)-N-phenylacetamide (CAS 626239-02-9)
- Abiraterone Impurity 12 (CAS CATO-C4X-107012)
- Vonoprazan Impurity 160 (CAS 2514735-12-5)
- Amlodipine Impurity N2 (CAS 111429-90-4)
- 2,3-Dihydro-5-Phenyl-7-(Trifluoromethoxy)-1H-1,4-Benzodiazepine (CAS 19337-66-7)
- 6-(4-Chlorobenzyl)-5-methyl-7-oxo-6,7-dihydroisothiazolo[4,3-d]pyrimidine-3-carboxylic acid (CAS 1779133-21-9)
- 2-(Trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid (CAS 73221-19-9)
- 6-Nitro-[1,2,4]triazolo[1,5-a]pyridine-2-sulfonyl chloride (CAS 1315367-30-6)
- (5-Chloro-2-(methylthio)pyrimidin-4-yl)(piperidin-1-yl)methanone (CAS 898648-51-6)
- Hesperidin Impurity 2 (CAS CATO-C4X-33272)
- Des-Ile17-Tirzepatide (CAS CATO-CPTD788956)
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