2-Chloro-N-(5-chloro-2-hydroxyphenyl)nicotinamide CAS 153144-00-4
| CAS No. | 153144-00-4 |
| Molecular Formula | C12H8Cl2N2O2 |
| Molecular Weight | 283.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 2-Chloro-N-(5-chloro-2-hydroxyphenyl)nicotinamide (CAS 153144-00-4), a certified reference material (molecular formula C12H8Cl2N2O2, MW 283.11 g/mol) for analytical method development and quality control.
2-Chloro-N-(5-chloro-2-hydroxyphenyl)nicotinamide (C12H8Cl2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures 2-Chloro-N-(5-chloro-2-hydroxyphenyl)nicotinamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H8Cl2N2O2 |
| Molecular Weight | 283.11 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 3-Chloro-4-(4-chlorophenoxy)benzoic acid (CAS 1384431-04-2)
- 2-Chloro-6-(2-chlorophenoxy)benzoic acid (CAS 76093-25-9)
- 2-Chloro-6-(4-chlorophenoxy)benzoic acid (CAS 76093-29-3)
- 5-Chloro-2-(3-chlorophenoxy)benzoic acid (CAS 69199-64-0)
- 5-chloro-6-[(4-chlorophenyl)amino]pyridine-3-carboxylic acid (CAS 942511-67-3)
- 2-chloro-1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilane 5565-32-2 Chlorotris(trimethylsilyl)silane (CAS 5565-32-2)
- 8-Chloro-6-fluoro-2H-chromene-3-sulfonyl chloride (CAS 1235440-07-9)
- methyl 4-chloro-5-(chlorosulfonyl)-2-methylbenzoate (CAS 102392-16-5)
Recommended Standards
- 1-[(4-Iodophenyl)methyl]-1H-pyrrole (CAS 143128-29-4)
- 4-Bromo-5-(butoxymethyl)-1-(difluoromethyl)-1H-pyrazole (CAS 1856019-59-4)
- 4-Bromo-3-((2,2-difluoroethoxy)methyl)-1-propyl-1H-pyrazole (CAS 1856028-30-2)
- 2-(2-(Iodomethyl)piperidin-1-yl)acetic acid (CAS 1353986-55-6)
- 1-[(2S)-2-Chloropyrrolidin-1-yl]-2-(cyclopentylamino)ethan-1-one (CAS 1881275-57-5)
- 3-(Difluoromethyl)-6-hydroxy-5-iodopicolinonitrile (CAS 1806846-39-8)
- 2-(5-Bromo-4-chloro-2-fluorophenyl)acetic acid (CAS 1780668-50-9)
- 1-Allyl-2-(2-chloropyridin-3-yl)-1H-benzo[d]imidazole (CAS 400081-26-7)
- 3-Morpholinopropane-1-sulfonyl chloride (CAS 103631-63-6)
- 6-Diazo-5-oxo-L-nor-Leucine (CAS 157-03-9)
- (S)-Hydrogen (2-hydroxy-3-(trimethylammonio)propyl)phosphonate (CAS 476493-48-8)
- trans-1-(bromomethyl)-2-methyl-cyclopropane (CAS 51598-33-5)
- Benzyl (2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate (CAS 1256359-14-4)
- Des-Leu26-Tirzepatide (CAS CATO-CPTD788947)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com