Ibuprofen Impurity 141 CAS 153153-85-6
| CAS No. | 153153-85-6 |
| Molecular Formula | C15H22O2 |
| Molecular Weight | 234.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Ibuprofen Impurity 141 (CAS 153153-85-6, C15H22O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Ibuprofen Impurity 141 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 234.33 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H22O2 |
| Molecular Weight | 234.33 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
Related Ibuprofen Standards
- Ibuprofen Impurity 35 (CAS 103775-30-6)
- Ibuprofen Impurity 30 (CAS 41283-72-1)
- Ibuprofen Impurity 34 (CAS CATO-C4X-1082134)
- Ibuprofen Carboxylic Acid (CAS 15935-54-3)
- Ibuprofen Carboxylic Acid-d3 (Mixture of Diastereomers) (CAS 1216505-29-1)
- Ibuprofen EP Impurity B Sodium (CAS CATO-C4X-108236)
- Ibuprofen Impurity 51 (CAS 43153-03-3)
- Ibuprofen Impurity 26 (CAS 67173-18-6)
Recommended Standards
- Procurcumenol (CAS 21698-40-8)
- Amorolfine Impurity 62 (CAS 1800302-57-1)
- (4aS,6S,8aR)-6-hydroxy-4,8a-dimethyl-6-(prop-1-en-2-yl)-4a,5,6,7,8,8a-hexahydronaphthalen-2(1H)-one (CAS 165898-48-6)
- Ionone Impurity 6 (CAS 72008-35-6)
- Mianserin Impurity 109 (CAS 4397-15-3)
- Ixazomib Impurity 72 (CAS CATO-C4X-126772)
- Ambroxol Impurity 35 (CAS CATO-C4X-108535)
- Tetrabutylphosphorus hydroxide solution (CAS 14518-69-5)
- 4,5-Dihydro-1,3-oxazol-2-amine (CAS 24665-93-8)
- 2-Chloroethyl 2,2,2-trifluoroacetate (CAS 40949-99-3)
- 2,2-Dichloro-6-methylacetanilide (CAS 6307-67-1)
- 2,3-Dihydro-1H-cyclopenta[b]quinoline-9-carboxylic acid (CAS 5447-47-2)
- Methyl 4-(2-hydroxyethoxy)benzoate (CAS 3204-73-7)
- Epidermal Growth Factor Receptor Peptide (985-996) (CAS 96249-43-3)
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