Ibuprofen Impurity 51 CAS 43153-03-3
| CAS No. | 43153-03-3 |
| Molecular Formula | C12H15ClO2 |
| Molecular Weight | 226.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Ibuprofen Impurity 51 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Ibuprofen Impurity 51 (CAS 43153-03-3), a pharmacopoeial impurity reference standard (molecular formula C12H15ClO2, MW 226.70 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C12H15ClO2, Ibuprofen Impurity 51 contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 226.70 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H15ClO2 |
| Molecular Weight | 226.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
| Halogen Content | Cl-containing |
Related Ibuprofen Standards
- Ibuprofen Impurity 26 (CAS 67173-18-6)
- Ibuprofen EP Impurity B Sodium (CAS CATO-C4X-108236)
- (S)-(+)-Ibuprofen Acid Chloride (CAS 115588-20-0)
- Ibuprofen Impurity 58 (CAS 80336-66-9)
- Ibuprofen Impurity 74 (CAS 1261642-35-6)
- Ibuprofen EP Impurity L (CAS 53949-53-4)
- Ibuprofen EP Impurity M (CAS 60057-62-7)
- Ibuprofen Impurity 27 (CAS 53949-54-5)
Recommended Standards
- 951-05-3 Phenanthrene, 9-(chloromethyl)- 9-(Chloromethyl)phenanthrene NSC 82368 (CAS 951-05-3)
- Risperidone EP Impurity L (CAS 63234-80-0)
- 258882-49-4 5-Chloro-1-(3-methoxyphenyl)pentan-1-one DTXSID30442116 (CAS 258882-49-4)
- Bilastine Impurity 40 (CAS 2199440-16-7)
- Atorvastatin Impurity 152 (CAS 191917-95-0)
- Chlorpromazine Impurity 13 (CAS 5845-30-7)
- Vazegepant Impurity 5 (CAS CATO-C4X-32005)
- 4-(Methylthio)-6-phenyl-1,3,5-triazin-2-amine (CAS 14945-93-8)
- 6-bromo-7-methyl-1H-indole (CAS 1000343-89-4)
- Valsartan Impurity 62 (CAS 1314799-75-1)
- 3-((6-Methylpyridin-2-yl)oxy)quinuclidine (CAS 2199972-15-9)
- (3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazol-5-yl)methyl acetate (CAS 1380089-34-8)
- 4-fluoro-7-nitro-1H-indazole (CAS 866144-02-7)
- Peptide 435 (CAS CATO-CPTD788435)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com