Rabeprazole 2-chloromethyl Impurity CAS 153259-31-5
| CAS No. | 153259-31-5 |
| Molecular Formula | C11H16ClNO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Rabeprazole 2-chloromethyl Impurity (C11H16ClNO2HCl) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 266.16 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies Rabeprazole 2-chloromethyl Impurity (CAS 153259-31-5), a pharmacopoeial impurity reference standard (molecular formula C11H16ClNO2HCl, MW 266.16 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Rabeprazole 2-chloromethyl Impurity meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H16ClNO2 HCl |
| Molecular Weight | 266.16 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Rabeprazole Standards
- Rabeprazole EP Impurity E (CAS 102804-77-3)
- Rabeprazole EP Impurity G (CAS 102804-82-0)
- Rabeprazole Impurity 9 (CAS 1114543-47-3)
- Rabeprazole 4-Chloro Analog Sulfone (CAS 1159977-27-1)
- Rabeprazole Impurity N1 (CAS 1163685-30-0)
- Rabeprazole Impurity 29 (CAS 1163685-31-1)
- Rabeprazole EP Impurity A (CAS 117976-47-3)
- Rabeprazole (CAS 117976-89-3)
Recommended Standards
- Amlodipine Impurity N8 (CAS 721958-75-4)
- Crisaborole Impurity 141 (CAS CATO-C4X-2021141)
- Calcitonin EP Impurity G (CAS CATO-C4X-22187)
- 1-(Trifluoromethoxy)-4-vinylbenzene (CAS 1736-08-9)
- Isoniazid EP Impurity D (CAS 553-53-7)
- Methyl 1,2,4-oxadiazole-3-carboxylate (CAS 89032-81-5)
- tert-Butyl chlorothioformate (CAS 13889-95-7)
- 2-Hydroxy-3-nitro-5-(trifluoromethoxy)benzaldehyde (CAS 2149597-24-8)
- N-Nitroso-N-Methyl-O-Methyl-Hydroxylamine (CAS 16339-12-1)
- Semaglutide impurity 271 (CAS CATO-C4X-2226271)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com