4,4-Difluoro-2,2-dimethylbutanoic acid CAS 1536988-56-3
| CAS No. | 1536988-56-3 |
| Molecular Formula | C6H10F2O2 |
| Molecular Weight | 152.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, 4,4-Difluoro-2,2-dimethylbutanoic acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 152.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
4,4-Difluoro-2,2-dimethylbutanoic acid (CAS 1536988-56-3), molecular formula C6H10F2O2 and molecular weight 152.14 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H10F2O2 |
| Molecular Weight | 152.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
Related Difluoro Standards
- 3,3-Difluoro-2,2-dimethylbutanoic acid (CAS 130021-54-4)
- 1,3-Difluoro-5-(1-Propyn-1-Yl)Benzene (CAS 153257-97-7)
- 2,2-difluoro-1-(oxolan-2-yl)ethan-1-ol (CAS 1548587-39-8)
- 5,6-Difluoro-1H-indene (CAS 161712-78-3)
- Methyl 3,3-difluoro-2,2-dimethylpropanoate (CAS 1849313-39-8)
- 4,4-Difluoro-3,3-dimethylbutanoic acid (CAS 1892397-17-9)
- [3,3-difluoro-1-(hydroxymethyl)cyclobutyl]methanol (CAS 1934699-78-1)
- 3,3-Difluoro-2-hydroxypent-4-enoic acid (CAS 1628332-54-6)
Recommended Standards
- 3-(2,2-Difluoroethoxy)cyclobutan-1-ol (CAS 1548013-54-2)
- 2-Ethyl-4,4-difluorobutanoic acid (CAS 1511599-27-1)
- 4-(Difluoromethyl)tetrahydro-2H-pyran-4-ol (CAS 1505220-12-1)
- Methyl 4,4-difluoropentanoate (CAS 1558369-72-4)
- Ethyl 4-(p-tolyl)thiazole-2-carboxylate (CAS 53101-01-2)
- 4-Aminomethyl-2,5-dimethyl-furan-3-carboxylicacid ethyl ester (CAS 883544-97-6)
- 2-(4-(Tert-pentyl)cyclohexyl)propanoic acid (CAS 1512012-57-5)
- 1-(3,4-Dimethylbenzyl)-1H-1,2,3-triazole-4-carbaldehyde (CAS 1494151-05-1)
- Acetaldehyde-13C2 (CAS 1632-98-0)
- N-(tert-Butyl)pteridin-4-amine (CAS 1707405-55-7)
- 1-(Benzo[d]thiazol-6-yl)cyclopropanecarboxylic acid (CAS 1006875-97-3)
- Efavirenz Impurity 5 (CAS 1189491-03-9)
- N-(3,4-dihydroxystyryl)acetamide (CAS 83104-76-1)
- Semaglutide impurity 71 (CAS CATO-C4X-222671)
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