1-(3-Chlorophenyl)pyrrolidine-2,5-dione CAS 15386-99-9
| CAS No. | 15386-99-9 |
| Molecular Formula | C10H8ClNO2 |
| Molecular Weight | 209.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(3-Chlorophenyl)pyrrolidine-2,5-dione.
1-(3-Chlorophenyl)pyrrolidine-2,5-dione (CAS 15386-99-9) is a high-purity analytical reference standard with the molecular formula C10H8ClNO2 and a molecular weight of 209.63 g/mol.
The molecular framework of 1-(3-Chlorophenyl)pyrrolidine-2,5-dione (C10H8ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(3-Chlorophenyl)pyrrolidine-2,5-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H8ClNO2 |
| Molecular Weight | 209.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chlorophenyl Standards
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- 3-(3-Chlorophenyl)-2-cyanopropionic Acid (CAS 1082249-01-1)
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- 1-(2-Chlorophenyl)-3-methyl-1H-1,2,4-triazol-5(4H)-one (CAS 109913-40-8)
- [1-(2-chlorophenyl)-1h-1,2,3-triazol-4-yl]methanol (CAS 1126635-72-0)
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Recommended Standards
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- 5-Chloro-7-methylindole-2-carboxylic Acid (CAS 15936-74-0)
- 7-methoxy-2-methyl-3-phenyl-4H-chromen-4-one (CAS 19725-44-1)
- 2-(Methoxymethyl)-thiophene-5-boronic acid pinacol ester (CAS 2102681-58-1)
- Aminoacetonitrile Hydrochloride (CAS 6011-14-9)
- 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE 2HCL (CAS 165894-07-5)
- 9-Octadecenoic acid, 12-hydroxy-, 2-hydroxyethyl ester, (9Z,12R)- (CAS 106-17-2)
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- 5-(4-Fluorophenyl)-1,2,4-oxadiazol-3-amine (CAS 1092340-67-4)
- 3-(3,5-Dimethoxyphenyl)propan-1-ol (CAS 1080-05-3)
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