Docetaxel Impurity 50 CAS 154306-81-7
| CAS No. | 154306-81-7 |
| Molecular Formula | C17H17NO2 |
| Molecular Weight | 267.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Docetaxel Impurity 50 (CAS 154306-81-7, C17H17NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C17H17NO2, Docetaxel Impurity 50 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 267.32 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H17NO2 |
| Molecular Weight | 267.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Nitrogen Atoms | 1 |
Related Docetaxel Standards
- Docetaxel Impurity 18 (CAS 146924-94-9)
- Docetaxel Impurity 19 (CAS 146924-91-6)
- Docetaxel Impurity 20 (CAS 194235-04-6)
- Docetaxel impurity 79 (CAS 194235-02-4)
- Docetaxel Impurity 23 (CAS 145514-62-1)
- Docetaxel Impurity 16 (CAS 161759-90-6)
- Docetaxel Impurity 66 (CAS 158830-39-8)
- Docetaxel Impurity 67 (CAS 124605-42-1)
Recommended Standards
- Atenolol EP Impurity G (CAS 56392-14-4)
- Esmolol Impurity 55 (CAS 33947-97-6)
- Sunitinib Impurity 43 (CAS 86770-31-2)
- Erdosteine Impurity 10 (CAS 121213-21-6)
- Ozagrel Impurity 43 (CAS CATO-C4X-197143)
- Lumateperone Impurity 68 (CAS CATO-C4X-220168)
- Lafutidine Impurity 11 (CAS 154923-16-7)
- 4-Bromo-6-methyl-7-azaindole (CAS 1000340-58-8)
- (S)-2-(((Benzyloxy)carbonyl)amino)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid (CAS 98409-91-7)
- N-(2-Methoxy-5-methylphenyl)-5-methylfuro[3,2-b]pyridine-2-carboxamide (CAS 941881-42-1)
- 1845AE 3-(4-Chlorophenyl)-1-phenyl-1H-pyrazole-4-carboxylic acid 372107-14-7 C16H11ClN2O2 (CAS 372107-14-7)
- Methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate (CAS 338417-50-8)
- 2-(3-Amino-piperidin-1-yl)-3h-thieno[3,2-d]pyrimidin-4-one (CAS 1248559-66-1)
- Semaglutide impurity 30 (CAS CATO-C4X-222630)
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