Docetaxel Impurity 19 CAS 146924-91-6
| CAS No. | 146924-91-6 |
| Molecular Formula | C16H15NO3 |
| Molecular Weight | 269.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Docetaxel Impurity 19.
As a process- or degradation-related impurity, Docetaxel Impurity 19 (CAS 146924-91-6, C16H15NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Docetaxel Impurity 19 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 269.30 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Docetaxel Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H15NO3 |
| Molecular Weight | 269.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 1 |
Related Docetaxel Standards
- Docetaxel Impurity 18 (CAS 146924-94-9)
- Docetaxel Impurity 20 (CAS 194235-04-6)
- Docetaxel impurity 79 (CAS 194235-02-4)
- Docetaxel Impurity 50 (CAS 154306-81-7)
- Docetaxel Impurity 23 (CAS 145514-62-1)
- Docetaxel Impurity 16 (CAS 161759-90-6)
- Docetaxel Impurity 66 (CAS 158830-39-8)
- Docetaxel Impurity 67 (CAS 124605-42-1)
Recommended Standards
- Phenylephrine Impurity 91 (CAS CATO-C4X-146791)
- Ampicillin Impurity 96 (CAS 35039-72-6)
- Ketorolac EP Impurity H (CAS 80965-09-9)
- 4-(2-(5-acetylpyridin-2-yl)ethoxy)benzaldehyde (CAS CATO-C4X-138355)
- Lapatinib Impurity 41 (CAS CATO-C4X-119141)
- Pyrantel EP Impurity B (CAS 36700-39-7)
- Alogliptin Impurity 102 (CAS CATO-C4X-1099102)
- 1-(4,6-Dihydrothieno[3,4-b]thien-2-yl)-2-ethyl-1-hexanone (CAS 1194605-72-5)
- 1-Bromo-3-(bromomethyl)-5-nitrobenzene (CAS 139194-80-2)
- (Z)-Dec-3-en-1-ol (CAS 10340-22-4)
- 2,2,2-Trichloro-1-(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)ethanol (CAS 1338494-96-4)
- 1,1''-Terphenyl, 3',4',5',6'-tetraphenyl- 992-04-1 Benzene, hexaphenyl- Hexaphenylbenzene NSC-220313 NSC220313 m-Terphenyl,4',5',6'-tetraphenyl- (CAS 992-04-1)
- (4-Chlorophenyl)(5-methyl-1,2,4-oxadiazol-3-yl)methanamine hydrochloride (CAS 1427379-58-5)
- Semaglutide impurity 197 (CAS CATO-C4X-2226197)
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