Iopromide EP Impurity F (Mixture of Diastereomers) CAS 154361-54-3
| CAS No. | 154361-54-3 |
| Molecular Formula | C21H28I3N3O9 |
| Molecular Weight | 847.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Iopromide EP Impurity F (Mixture of Diastereomers) (CAS 154361-54-3) is a certified pharmaceutical impurity reference standard with the molecular formula C21H28I3N3O9 and a molecular weight of 847.18 g/mol.
The molecular framework of Iopromide EP Impurity F (Mixture of Diastereomers) (C21H28I3N3O9) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H28I3N3O9 |
| Molecular Weight | 847.18 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 3 |
Related Iopromide Standards
- Iopromide impurity 15 (CAS CATO-C4X-183215)
- Iopromide Impurity 10 (CAS 76801-94-0)
- Iopromide impurity 13 (CAS CATO-C4X-183213)
- Iopromide impurity 14 (CAS CATO-C4X-183214)
- Iopromide EP Impurity G (Mixture of Diastereomers) (CAS 154361-53-2)
- Iopromide-[d3] (CAS 1189947-73-6)
- Iopromide Impurity 24 (CAS 1651211-76-5)
- Iopromide (CAS 73334-07-3)
Recommended Standards
- Diacetate{2,2'-bis(diphenylphosphino)-1,1'-binaphthyl}palladium(II) (CAS 331749-09-8)
- Ubidecarenone impurity 21 (CAS CATO-C4X-137621)
- Polidocanol Impurity 5 (Polidocanol E15) (CAS 54350-54-8)
- Nickelate(4-), [[4,4',4'',4'''-(21H,23H-porphine-5,10,15,20-tetrayl)tetrakis[benzoato]](6-)-N21,N22,N23,N24]-, tetrahydrogen, (SP-4-1)- (CAS 41699-92-7)
- Clevidipine butyrate Impurity 11 (CAS 138279-32-0)
- Regorafenib Impurity 43 (CAS 1798046-84-0)
- Carprofen EP Impurity A (CAS 252288-17-8)
- Tedizolid Impurity 59 (CAS 2095100-93-7)
- 5-(Furan-2-yl)-1-(methylsulfonyl)-3-(o-tolyl)-4,5-dihydro-1H-pyrazole (CAS 1448048-27-8)
- Methyl 2-(3-fluoro-4-hydroxyphenyl)acetate (CAS 79280-92-5)
- 1,5-Dimethyl (2E,4Z)-4-[(benzylamino)methylidene]pent-2-enedioate (CAS 78408-80-7)
- Indometacin EP Impurity C (CAS 4018-82-0)
- 2-(Benzyl(4,5-dihydrothiazol-2-yl)amino)-1-(p-tolyl)ethan-1-one hydrobromide (CAS 351525-97-8)
- Tau Peptide (277-291) trifluoroacetate salt (CAS 330456-40-1)
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