Regorafenib Impurity 43 CAS 1798046-84-0
| CAS No. | 1798046-84-0 |
| Molecular Formula | C12H8ClFN2O2 |
| Molecular Weight | 266.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Regorafenib Impurity 43 (C12H8ClFN2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Regorafenib Impurity 43 (CAS 1798046-84-0) is a certified pharmaceutical impurity reference standard with the molecular formula C12H8ClFN2O2 and a molecular weight of 266.66 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Regorafenib Impurity 43 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H8ClFN2O2 |
| Molecular Weight | 266.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Regorafenib Standards
- Regorafenib Impurity 40 (CAS 2711-18-4)
- Regorafenib Impurity 31 (CAS CATO-C4X-104731)
- Regorafenib Impurity 36 (CAS 864245-61-4)
- Regorafenib EP Impurity A (CAS 757251-39-1)
- Regorafenib Impurity 32 (CAS CATO-C4X-104732)
- Regorafenib Impurity 51 (CAS CATO-C4X-104751)
- Regorafenib Impurity 72 (CAS CATO-C4X-104772)
- Regorafenib Impurity 63 (CAS CATO-C4X-104763)
Recommended Standards
- Methyl 4-(2-Chloro-5-fluoro-4-pyrimidinyl)benzoate (CAS 663611-72-1)
- ethyl 4-(chlorosulfonyl)-3-fluorobenzoate (CAS 1063734-43-9)
- 6-Chloro-3-fluoro-N-(5-methylpyrazin-2-yl)picolinamide (CAS 2438941-79-6)
- Ethyl 3-(chlorosulfonyl)-5-fluorobenzoate (CAS 1154154-93-4)
- Tenofovir disoproxil impurity 123 (CAS 1962114-92-6)
- Rivaroxaban Impurity 63 (CAS 6324-63-6)
- Teriparatide Impurity 3 (Teri-Met 8(O)) (CAS CATO-C4X-21853)
- 2-(2-Bromophenyl)acetamide (CAS 65999-53-3)
- 5-Chloro-2-(3,4-dihydroisoquinolin-2(1H)-yl)aniline (CAS 893751-51-4)
- 4-Methyl-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde (CAS 1256804-60-0)
- Esmolol Impurity 76 (CAS CATO-C4X-189176)
- (R)-2-((tert-butoxycarbonyl)amino)-4-(4-methoxyphenyl)butanoic acid (CAS 1260589-40-9)
- N-(5-Benzoyl-2-oxo-4-phenylpyrimidin-1(2H)-yl)benzamide (CAS 832733-39-8)
- Semaglutide impurity 45 (CAS CATO-C4X-222645)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com