N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide CAS 154934-69-7
| CAS No. | 154934-69-7 |
| Molecular Formula | C12H5ClF5N3O |
| Molecular Weight | 337.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 337.63 g/mol gives N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide (CAS 154934-69-7) is a high-purity analytical reference standard with the molecular formula C12H5ClF5N3O and a molecular weight of 337.63 g/mol.
The molecular framework of N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide (C12H5ClF5N3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H5ClF5N3O |
| Molecular Weight | 337.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related N Standards
- N-((1-(3,4-Difluorophenyl)-1H-tetrazol-5-yl)methyl)-2-propylpentanamide (CAS 941963-88-8)
- n-(3,4-Difluorophenyl)-2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide (CAS 742116-09-2)
- N-(2,4-Difluorophenyl)-4-(trifluoromethyl)benzenesulfonamide (CAS 1243324-15-3)
- 1-(2,4-Difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid (CAS 103995-01-3)
- N1-(2,5-Difluorophenyl)-N2-(2-(4-fluorophenoxy)ethyl)oxalamide (CAS 1207054-24-7)
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- N1-(2,5-Difluorophenyl)-N2-((1-(thiophen-2-yl)cyclopropyl)methyl)oxalamide (CAS 1207043-63-7)
- 1-((1-(3,4-Difluorophenyl)-1H-tetrazol-5-yl)methyl)-3-(thiophen-2-yl)urea (CAS 941965-14-6)
Recommended Standards
- 3-Methyl-1-phenyl-5-(2,4,5-trichlorophenyl)-1H-pyrazole (CAS 1261667-98-4)
- 2,2,2-Trichloro-1-(4-(2-methoxyphenyl)piperazin-1-yl)ethanone (CAS 219963-59-4)
- (2R)-2-[Diphenyl[(trimethylsilyl)oxy]methyl]pyrrolidine (R)-(+)-|A,|A-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether (R)-(+)-|A,|A-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether solution (R)-2-[Diphenyl(trimethylsilanyloxy)methyl]pyrrolidine (R)-2-[Diphenyl(trimethylsilanyloxy)methyl]pyrrolidine solution (R)-|A,|A-Diphenylprolinol trimethylsilyl ether (R)-|A,|A-Diphenylprolinol trimethylsilyl ether solution 943757-71-9 (CAS 943757-71-9)
- 2-chloro-N-{2-[(2,5-dichlorophenyl)amino]-2-oxoethyl}-N-propylacetamide (CAS 733031-22-6)
- [3-(3,5-dimethoxyphenoxy)propyl](methyl)amine hydrochloride (CAS 1384430-92-5)
- 9-Fluoro-1,2,3,4,5,6-hexahydroazepino[4,3-b]indole (CAS 919120-68-6)
- 5-(Pyridin-3-yl)thiophen-2-amine (CAS 837376-58-6)
- Ethyl 1-ethyl-5-hydroxy-2-methyl-1h-indole-3-carboxylate (CAS 49742-74-7)
- Ethyl 2-amino-4-chloro-3-methoxybenzoate (CAS 1247605-97-5)
- 2-Chloro-6-(furan-2-yl)pyridine-3-carbonitrile (CAS 946385-82-6)
- 5-(Thiophen-2-yl)pyrimidin-2-ol (CAS 1111113-73-5)
- 2-(2-(Cyclopropylmethoxy)ethoxy)ethane-1-sulfonyl chloride (CAS 1339409-65-2)
- 5-Bromo-2-hydrazinyl-3-nitropyridine (CAS 15862-42-7)
- Liraglutide Impurity 14 TFA Salt (CAS CATO-C4X-199214)
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