N3-(2,4-Difluorophenyl)-2-chloro-4-(trifluoromethyl)nicotinamide CAS 288246-33-3

Description

As a certified reference material (CRM), N3-(2,4-Difluorophenyl)-2-chloro-4-(trifluoromethyl)nicotinamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

N3-(2,4-Difluorophenyl)-2-chloro-4-(trifluoromethyl)nicotinamide (CAS 288246-33-3), molecular formula C13H6ClF5N2O and molecular weight 336.64 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of N3-(2,4-Difluorophenyl)-2-chloro-4-(trifluoromethyl)nicotinamide (C13H6ClF5N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

Physical & Chemical Properties

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