6-(Trifluoromethyl)piperidine-2,4-dione CAS 1552231-27-2
| CAS No. | 1552231-27-2 |
| Molecular Formula | C6H6F3NO2 |
| Molecular Weight | 181.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
6-(Trifluoromethyl)piperidine-2,4-dione (CAS 1552231-27-2), molecular formula C6H6F3NO2 and molecular weight 181.11 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-(Trifluoromethyl)piperidine-2,4-dione (C6H6F3NO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H6F3NO2 |
| Molecular Weight | 181.11 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 5-(Trifluoromethyl)-3,4-dihydro-2H-pyrrole-2-carboxylic acid (CAS 1609965-85-6)
- 4-(Trifluoromethyl)piperidine-2,6-dione (CAS 356518-29-1)
- 5-Methyl-5-(trifluoromethyl)pyrrolidine-2,4-dione (CAS 1997200-27-7)
- [1-Methyl-5-(trifluoromethyl)-1H-1,2,3-triazol-4-yl]methanol (CAS 1267796-04-2)
- 2-[3-(Trifluoromethyl)-1H-1,2,4-triazol-1-yl]ethanol (CAS 1706431-23-3)
- 2-(5-(Trifluoromethyl)-1,3,4-oxadiazol-2-yl)ethan-1-amine (CAS 944898-34-4)
- 2-[3-(Trifluoromethyl)-1,2,4-oxadiazol-5-yl]ethan-1-amine (CAS 944905-86-6)
- 2-Trifluoromethyl-4-thiazolecarboxaldehyde (CAS 133046-48-7)
Recommended Standards
- 1-(2,2,2-Trifluoroethyl)pyrrolidine-2,4-dione (CAS 1513582-88-1)
- 1-(3,6-Dihydro-2H-1,2-Oxazin-2-Yl)-2,2,2-Trifluoroethanone (CAS 13627-94-6)
- 1-(6-Oxa-3-azabicyclo[3.1.0]hexan-3-yl)-2,2,2-trifluoroethanone (CAS 164931-85-5)
- Pyrimido[4,5-e][1,2,4]triazine-3,6,8(2H,5H,7H)-trione (CAS 13538-84-6)
- 2-Methylhex-5-enoic acid (CAS 77290-89-2)
- Methyl 2-hydroxy-3-(1-oxidothiomorpholino)propanoate (CAS 1864891-64-4)
- Naxagolide (CAS 88058-88-2)
- 6,7-Dibromo-2,3-dihydro-1H-inden-1-one (CAS 1344903-40-7)
- Methyl 2,5-dimethyl-4-nitrobenzoate (CAS 953393-97-0)
- Glycerol-2-13C (CAS 82425-96-5)
- ethyl 5-cyclopropyl-3-methyl-1,2-oxazole-4-carboxylate (CAS 1461707-89-0)
- 2-((1-Methylpiperidin-4-yl)amino)ethanol (CAS 56709-51-4)
- Azido-PEG3-methyl ester (CAS 2086689-07-6)
- Neuropeptide SF (human) (CAS 192387-39-6)
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