Gadobutrol Impurity 125 CAS 156077-56-4
| CAS No. | 156077-56-4 |
| Molecular Formula | C12H28N4O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Gadobutrol Impurity 125 (CAS 156077-56-4), a pharmacopoeial impurity reference standard (molecular formula C12H28N4O3HCl, MW 312.84 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Gadobutrol Impurity 125 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 312.84 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H28N4O3 4*HCl |
| Molecular Weight | 312.84 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Gadobutrol Standards
- Gadobutrol Impurity 112 (CAS 1003-83-4)
- Gadobutrol Impurity 12 4HCl (CAS 10045-25-7)
- Gadobutrol Impurity 79 (CAS 105855-71-8)
- Gadobutrol Impurity 115 (CAS 112-24-3)
- Gadobutrol EP Impurity C (Gadoteridol USP Related Compound B) (CAS 112188-16-6)
- Gadobutrol Impurity N5 (CAS 112193-75-6)
- Gadobutrol Impurity 104 4HCl (CAS 112193-75-6（free base）)
- Gadobutrol Impurity 37 (Cyclen Disulfate) (CAS 112193-77-8)
Recommended Standards
- Dyclonine Impurity 1 (CAS 95605-38-2)
- Buspirone EP Impurity H HCl (CAS CATO-C4X-12588)
- Meropenem Impurity 53 (CAS CATO-C4X-130953)
- 1-tert-Butyl-3,5-dimethyl-1h-pyrazol-4-ol (CAS 1466743-75-8)
- 6-Ethynyl-1,2,3,4-tetrahydronaphthalene (CAS 408320-46-7)
- 6-Bromo-2,3-dihydrobenzo[b]thiophene 1,1-Dioxide (CAS 61942-64-1)
- 2-(2-Amino-4-fluorophenyl)propan-2-ol (CAS 1009368-27-7)
- (S)-3,4-Dimethoxy-alpha-methylbenzylamine (CAS 65451-89-0)
- 1-Methyl-2-{[(4-methylphenyl)methyl]sulfanyl}-4,5-diphenyl-1H-imidazole (CAS 339277-98-4)
- Tirzepatide-d7 Ditrifluoroacetate (CAS CATO-CPTD788698)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com