Rapamycin Impurity 6 CAS 156223-31-3
| CAS No. | 156223-31-3 |
| Molecular Formula | C50H77NO13 |
| Molecular Weight | 900.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Rapamycin Impurity 6 (C50H77NO13) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Rapamycin Impurity 6 (CAS 156223-31-3, C50H77NO13) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Rapamycin Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C50H77NO13 |
| Molecular Weight | 900.15 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Nitrogen Atoms | 1 |
Related Rapamycin Standards
- Rapamycin Aldehyde Degrades Impurity (CAS CATO-C4X-174628)
- Rapamycin Impurity 12 (CAS 150821-39-9)
- Rapamycin Impurity 19 (CAS 144293-63-0)
- Rapamycin Impurity 21 (CAS 151945-42-5)
- Rapamycin Impurity 24 (CAS CATO-C4X-174624)
- Rapamycin Impurity 25 (CAS 151945-42-5 (racemic))
- Rapamycin Dehydration Impurity (CAS CATO-C4X-174627)
- Rapamycin Impurity 29 (CAS CATO-C4X-174629)
Recommended Standards
- 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,18-Pentatriacontafluorooctadecan-1-ol (CAS 242142-82-1)
- 42-O-Desmethyl Rapamycin (CAS 142382-16-9)
- 3,5-Bis(perfluoro-1-hexyl)-1-(heptafluorobutyl)-1H-pyrazole (CAS 247113-85-5)
- 7-O-Demethyl Rapamycin (CAS 151519-50-5)
- Indocyanine Green N-Oxide (CAS CATO-C4X-250330)
- Dolutegravir Impurity 36 (CAS CATO-C4X-162036)
- Mupirocin Impurity 30 (CAS 40980-52-7)
- 1-Ethyl-2-methylquinolin-4(1H)-one (CAS 15574-80-8)
- Eperisone Impurity 3 (CAS CATO-C4X-22793)
- 2-(3-Chlorophenyl)-4,5,6,7-tetrahydrooxazolo[4,5-c]pyridine (CAS 944903-54-2)
- (3aR,6aS)-2-[(4-methoxyphenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole (CAS 1807937-91-2)
- 6-Chloro-2-(2-((5-nitrofuran-2-yl)methylene)hydrazinyl)-4-phenylquinazoline (CAS 327039-18-9)
- 5-Bromo-3-chloroimidazo[1,2-a]pyridine (CAS 69214-13-7)
- Liraglutide Impurity 13 TFA Salt (CAS CATO-C4X-199213)
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