8-Chloro-6-fluoroquinazolin-4(3H)-one CAS 1564541-96-3
| CAS No. | 1564541-96-3 |
| Molecular Formula | C8H4ClFN2O |
| Molecular Weight | 198.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 198.58 g/mol gives 8-Chloro-6-fluoroquinazolin-4(3H)-one distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
8-Chloro-6-fluoroquinazolin-4(3H)-one (CAS 1564541-96-3) is a high-purity analytical reference standard with the molecular formula C8H4ClFN2O and a molecular weight of 198.58 g/mol.
The molecular framework of 8-Chloro-6-fluoroquinazolin-4(3H)-one (C8H4ClFN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 8-Chloro-6-fluoroquinazolin-4(3H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4ClFN2O |
| Molecular Weight | 198.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-(2-Chloro-6-fluorophenyl)-1,3,4-oxadiazole (CAS 1171931-06-8)
- 5-Chloro-3-(3-fluorophenyl)-1,2,4-oxadiazole (CAS 1184059-45-7)
- 4-Chloro-5-fluoro-7H-pyrrolo[2,3-b]pyridine-6-carbaldehyde (CAS 1246088-61-8)
- 5-(2-Chloro-4-fluorophenyl)-2H-tetrazole (CAS 1261268-87-4)
- 3-(4-Chloro-2-fluorophenyl)propiolic acid (CAS 1339870-06-2)
- 3-Chloro-6-fluoroquinoxalin-2(1H)-one (CAS 1374748-36-3)
- 4-Chloro-7-fluoroquinazolin-6-ol (CAS 1379203-47-0)
- 5-Chloro-1-(4-fluorophenyl)-1H-tetrazole (CAS 14210-27-6)
Recommended Standards
- 7-chloro-8-fluoro-3,4-dihydroquinazolin-4-one (CAS 1566199-72-1)
- 8-Chloro-5-fluoroquinazolin-4(3H)-one (CAS 1697327-18-6)
- Afatinib Impurity 28 (CAS 17519-02-7)
- 2-(4-Chloro-2-fluorophenyl)-1,3,4-oxadiazole (CAS 1820711-18-9)
- 5-chloro-4-cyclopropylpyridine-2-carboxylic acid (CAS 1256790-87-0)
- 2-(Fluoranthen-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 863878-53-9)
- (5-Phenyloxazol-4-yl)methanamine (CAS 933694-58-7)
- N-(5-Amino-2-fluorophenyl)-4-(heptyloxy)benzamide (CAS 1020057-40-2)
- 3-Hydroxy-3-(2-(4-methoxyphenyl)-2-oxoethyl)indolin-2-one (CAS 70452-26-5)
- tert-Butyl 3-iodo-5-methyl-6,7-dihydropyrazolo[1,5-a]pyrimidine-4(5H)-carboxylate (CAS 2770271-24-2)
- 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one (CAS 76282-95-6)
- 1-(2-Carboxyphenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid (CAS 956990-21-9)
- 1-((3-(Dimethylamino)propyl)amino)-4-hydroxyanthracene-9,10-dione (CAS 38866-17-0)
- Semaglutide impurity 60 (CAS CATO-C4X-222660)
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