1-(2-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Methyl Ester CAS 1568-35-0
| CAS No. | 1568-35-0 |
| Molecular Formula | C20H18ClNO4 |
| Molecular Weight | 371.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(2-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Methyl Ester (CAS 1568-35-0) is a high-purity analytical reference standard with the molecular formula C20H18ClNO4 and a molecular weight of 371.81 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 1-(2-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Methyl Ester is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 371.81 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H18ClNO4 |
| Molecular Weight | 371.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chlorobenzoyl Standards
- 1-(3-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Methyl Ester (CAS 1568-36-1)
- N-(4-Chlorobenzoyl)-2-(2,4-dichlorophenoxy)ethanehydrazonamide (CAS 338395-78-1)
- 2-{[4-(2-Chlorobenzoyl)piperazin-1-yl]carbonyl}benzoic acid (CAS 896508-49-9)
- (2E)-2-[5-(4-Chlorobenzoyl)thiophen-2-yl]-3-(3-methylthiophen-2-yl)prop-2-enenitrile (CAS 338966-69-1)
- N-(4-Chlorobenzoyl)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetohydrazide (CAS 339105-83-8)
- 339010-20-7 4-{[(4-chlorobenzoyl)oxy]imino}-1-(4-nitrophenyl)piperidine KS-00003CG1 (CAS 339010-20-7)
- N-(2-(2-chlorobenzoyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)-4-methylbenzamide (CAS 478031-94-6)
- 4-({[(4-chlorobenzoyl)amino]carbonyl}amino)-3-fluorobenzene-1-sulphonyl fluoride (CAS 284674-50-6)
Recommended Standards
- (2S,4S)-1-(tert-Butoxycarbonyl)-4-(2-chloro-4-methoxyphenoxy)-2-pyrrolidinecarboxylic acid (CAS 1354486-68-2)
- 3-(4-Chlorophenyl)-9-(3-hydroxypropyl)-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one (CAS 1010933-62-6)
- 3-(n-Benzyl4-chloro-2-fluorobenzenesulfonamido)propanoic acid (CAS 794584-40-0)
- Avanafil Impurity 56 (CAS 2310299-29-5)
- 3-(2-Bromophenyl)-N-(4-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)phenyl)propanamide (CAS 1448128-50-4)
- Benzyl Azetidin-3-ylcarbamate (CAS 914348-04-2)
- 5-Isobutoxy-1,2-dimethyl-1h-indole-3-carbaldehyde (CAS 1266373-75-4)
- 4-(2,4-Difluorophenoxy)butan-1-amine (CAS 1016744-43-6)
- 4-(2-Amino-5H-thiazolo[4,3-b][1,3,4]thiadiazol-5-yl)phenol (CAS 1310810-99-1)
- N-(3-Methylpyridin-2-yl)-2-(5-phenylisoxazol-3-yl)acetamide (CAS 953152-55-1)
- 1-Chloro-2-Nitrobenzene (CAS 88-73-3)
- 3-(2,5-Dimethoxyphenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (CAS 1283108-50-8)
- Poly(lactide-co-glycolide) 6-arm dipentaerythritol initiated (55:45 LA:GA, Mn 40,000 – 60,000 Da) (CAS CATO-C3D-263088)
- Tau Peptide (268-282) trifluoroacetate salt (CAS 330456-37-6)
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