Boceprevir Impurity 21 CAS 1568066-82-9
| CAS No. | 1568066-82-9 |
| Molecular Formula | C8H12F3NO3 |
| Molecular Weight | 227.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Boceprevir Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Boceprevir Impurity 21 (CAS 1568066-82-9, C8H12F3NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Boceprevir Impurity 21 (C8H12F3NO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H12F3NO3 |
| Molecular Weight | 227.18 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Boceprevir Standards
- Boceprevir Impurity 16 (CAS CATO-C4X-252516)
- Boceprevir Impurity 18 (CAS CATO-C4X-252518)
- Boceprevir Impurity 19 (CAS CATO-C4X-252519)
- Boceprevir Impurity 10 (CAS CATO-C4X-252510)
- Boceprevir Impurity 20 (CAS 328086-57-3)
- Boceprevir Impurity 2 (CAS CATO-C4X-25252)
- Boceprevir Impurity 1 (CAS 943516-56-1)
- Boceprevir Impurity 15 (CAS CATO-C4X-252515)
Recommended Standards
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- methyl 2-(2-fluoro-4-nitrophenyl)propanoate (CAS 104784-47-6)
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- 6-Bromo-3,3-dimethylindolin-2-one (CAS 158326-84-2)
- Potassium D-tartrate (CAS 57341-16-9)
- 1,1,1,3,3,3-Hexafluoro-2-(3-fluoro-4-iodophenyl)propan-2-ol (CAS 1358953-45-3)
- Des-Ala28-Tirzepatide (CAS CATO-CPTD788945)
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