2,5-Difluorophenylacetyl chloride CAS 157033-23-3
| CAS No. | 157033-23-3 |
| Molecular Formula | C8H5ClF2O |
| Molecular Weight | 190.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2,5-Difluorophenylacetyl chloride (C8H5ClF2O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies 2,5-Difluorophenylacetyl chloride (CAS 157033-23-3), a certified reference material (molecular formula C8H5ClF2O, MW 190.57 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF2O |
| Molecular Weight | 190.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | F/Cl-containing |
Recommended Standards
- 5-Chloro-2-(difluoromethyl)benzaldehyde (CAS 1554368-81-8)
- 2-(3,5-Difluorophenyl)ethanoyl chloride, 98% (CAS 157033-24-4)
- 1-(3-Chloro-2,4-difluorophenyl)ethanone (CAS 154258-06-7)
- 6-Chloro-2,4-difluoro-3-methylbenzaldehyde (CAS 1706435-05-3)
- 5-((4-Chlorophenyl)thio)thiophene-2-sulfonamide (CAS 63031-81-2)
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- 5-(tert-Butyl)benzo[b]thiophen-3(2H)-one (CAS 79097-32-8)
- (S)-1-(4-Bromophenyl)-2,2-dimethylpropan-1-amine hydrochloride (CAS 2411591-67-6)
- 4-Amino-5-(cyclopentylmethoxy)furan-2(5H)-one (CAS 370876-84-9)
- MEthyl 5-(4-bromophenyl)-1-(4-ethylphenyl)-2-methyl-1h-pyrrole-3-carboxylate (CAS 881040-08-0)
- 1-Phenyl-3-(quinoxalin-6-yl)urea (CAS 177264-55-0)
- Crizotinib Impurity 48 (CAS CATO-C4X-102548)
- Semaglutide Impurity 189 (CAS CATO-C4X-2226189)
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