Crizotinib Impurity 48 CAS CATO-C4X-102548
| CAS No. | CATO-C4X-102548 |
| Molecular Formula | C21H23ClFN5O |
| Molecular Weight | 415.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Crizotinib Impurity 48 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Crizotinib Impurity 48 (CAS CATO-C4X-102548), a pharmacopoeial impurity reference standard (molecular formula C21H23ClFN5O, MW 415.89 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C21H23ClFN5O, Crizotinib Impurity 48 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 415.89 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C21H23ClFN5O |
| Molecular Weight | 415.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Crizotinib Standards
- Crizotinib impurity 30 (CAS CATO-C4X-102530)
- Crizotinib impurity 31 (CAS CATO-C4X-102531)
- Crizotinib impurity 32 (CAS CATO-C4X-102532)
- Crizotinib Impurity 41 (CAS 1801651-84-2)
- Crizotinib Impurity 49 (CAS CATO-C4X-102549)
- Crizotinib Impurity 74 (CAS CATO-C4X-102574)
- Crizotinib Impurity 55 (CAS CATO-C4X-102555)
- Crizotinib impurity 29 (CAS CATO-C4X-102529)
Recommended Standards
- N-(1-(1-(4-Chlorophenyl)-1H-1,2,3-triazole-4-carbonyl)piperidin-4-yl)thiophene-2-carboxamide (CAS 1251696-23-7)
- 2-((4-Allyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(3-chloro-4-methoxyphenyl)acetamide (CAS 577762-32-4)
- 3-(4-((4-Chlorophenyl)sulfonyl)piperazin-1-yl)-6-(pyridin-4-yl)pyridazine (CAS 946213-54-3)
- Milenperone (CAS 59831-64-0)
- Regadenoson Impurity 15 (CAS 2015222-35-0)
- Vibegron Impurity 7 (CAS CATO-C4X-23767)
- Linagliptin Impurity 92 (CAS 168749-30-2)
- N-((1H-Benzo[d]imidazol-2-yl)methyl)-3-methoxybenzamide (CAS 862488-30-0)
- (S)-4-tert-Butyl-2-oxazolidinone (CAS 54705-42-9)
- tert-butyl 3-(cyanomethyl)-3-(hydroxymethyl)azetidine-1-carboxylate (CAS 2413097-50-2)
- 4-((Dimethylamino)methyl)benzenesulfonamide (CAS 1547880-06-7)
- 4-Cyano-3-(5,5-Dimethyl-[1,3,2]dioxaborinan-2-yl)-pyridine (CAS 868944-72-3)
- 2-Phenyl-1-(tetrahydro-2H-pyran-2-yl)ethanone (CAS 100612-18-8)
- Semaglutide impurity 49 (CAS CATO-C4X-222649)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com