Rapamycin Impurity 10 CAS 157054-84-7
| CAS No. | 157054-84-7 |
| Molecular Formula | C52H81NO13 |
| Molecular Weight | 928.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Rapamycin Impurity 10 (CAS 157054-84-7, C52H81NO13) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C52H81NO13, Rapamycin Impurity 10 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 928.20 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C52H81NO13 |
| Molecular Weight | 928.20 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Nitrogen Atoms | 1 |
Related Rapamycin Standards
- Rapamycin Impurity 11 (CAS 159351-88-9)
- 33-Ethyl Rapamycin (CAS CATO-C4X-174617)
- Rapamycin Impurity 23 (CAS CATO-C4X-174623)
- Rapamycin Impurity 8 (CAS CATO-C4X-17468)
- Rapamycin Impurity 22 (CAS 185107-79-3)
- Rapamycin Impurity 32 (CAS CATO-C4X-174632)
- Rapamycin Impurity 12 (CAS 150821-39-9)
- Rapamycin Impurity 19 (CAS 144293-63-0)
Recommended Standards
- 16753-33-6 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,18-pentatriacontafluorooctadecanoic acid methyl ester A810878 methyl 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,18-pentatriacontakis(fluoranyl)octadecanoate (CAS 16753-33-6)
- 8-Oxo-Eprinomectin B1a (CAS CATO-C4X-21291)
- 28-demethyl-28-ethyl-Rapamycin (CAS 1290606-22-2)
- Rifamycin Impurity 15 (CAS CATO-C4X-200415)
- Imatinib Impurity 95 (CAS CATO-C4X-106895)
- Oxcarbazepine EP Impurity H (CAS 4698-11-7)
- Alectinib Impurity 86 (CAS CATO-C4X-283686)
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