2-(2,4-Difluorophenyl)-2-propenyl-propanedioic acid diethyl ester CAS 159276-62-7
| CAS No. | 159276-62-7 |
| Molecular Formula | C16H18F2O4 |
| Molecular Weight | 312.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(2,4-Difluorophenyl)-2-propenyl-propanedioic acid diethyl ester.
CATO supplies 2-(2,4-Difluorophenyl)-2-propenyl-propanedioic acid diethyl ester (CAS 159276-62-7), a certified reference material (molecular formula C16H18F2O4, MW 312.31 g/mol) for analytical method development and quality control.
The molecular framework of 2-(2,4-Difluorophenyl)-2-propenyl-propanedioic acid diethyl ester (C16H18F2O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H18F2O4 |
| Molecular Weight | 312.31 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | F-containing |
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Recommended Standards
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- 2-(Pyridin-2-ylthio)-N-(4-(trifluoromethyl)phenyl)acetamide (CAS 444165-93-9)
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- ((1S,4r)-4-propylcyclohexyl)methyl methanesulfonate (CAS 2071203-42-2)
- <I>O</I>-isopropylxanthate potassium salt (CAS 140-92-1)
- 4-Methoxyquinolin-7-amine (CAS 1354222-20-0)
- methyl 2-(5-hydroxynaphthalen-1-yl)acetate (CAS 497068-60-7)
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- Dulaglutide (CAS 923950-08-7)
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