3-(2,6-Difluorophenyl)-4-(pyrrolidin-1-ylmethyl)thiazole-2(3H)-thione CAS 866153-90-4

Description

3-(2,6-Difluorophenyl)-4-(pyrrolidin-1-ylmethyl)thiazole-2(3H)-thione (CAS 866153-90-4), molecular formula C14H14F2N2S2 and molecular weight 312.40 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 3-(2,6-Difluorophenyl)-4-(pyrrolidin-1-ylmethyl)thiazole-2(3H)-thione (C14H14F2N2S2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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