Temsirolimus impurity 1 CAS 159351-68-5
| CAS No. | 159351-68-5 |
| Molecular Formula | C59H97NO14Si |
| Molecular Weight | 1072.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Temsirolimus impurity 1 (CAS 159351-68-5) is a certified pharmaceutical impurity reference standard with the molecular formula C59H97NO14Si and a molecular weight of 1072.49 g/mol.
Based on its molecular formula C59H97NO14Si, Temsirolimus impurity 1 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 1072.49 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C59H97NO14Si |
| Molecular Weight | 1072.49 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Nitrogen Atoms | 1 |
Related Temsirolimus Standards
Recommended Standards
- Everolimus Impurity 28 (CAS CATO-C4X-112228)
- 2,5-Dioxopyrrolidin-1-yl 4-((3-((3-(((2S)-1-(((14S,16S,33S,2R,4R,10E,12Z,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl)oxy)-1-oxopropan-2-yl)(methyl)amino)-3-oxopropyl)thio)-2,5-dioxopyrrolidin-1-yl)methyl)cyclohexane-1-carboxylate (CAS 1228105-51-8)
- Everolimus Impurity 20 (CAS CATO-C4X-112220)
- (4,8-Bis(5-(2-ethylhexyl)-4-hexylthiophen-2-yl)benzo[1,2-b:4,5-b']dithiophene-2,6-diyl)bis(trimethylstannane) (CAS 1627681-05-3)
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- 5-(2,6-Dimethylmorpholino)-2-nitrophenol (CAS 175135-20-3)
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- 3-(1-Methylindolin-5-yl)propan-1-amine (CAS 1250348-09-4)
- 5-(Hydroxy(phenyl)methyl)-4-methylpyridine-2(1H)-thione (CAS 1355193-35-9)
- Liraglutide Impurity 17 TFA Salt (CAS CATO-C4X-199217)
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